論文 - 詳細
RRC ID | 40064 |
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著者 | Saito T, Itabashi T, Wakana D, Takeda H, Yaguchi T, Kawai K, Hosoe T. |
タイトル | Isolation and structure elucidation of new phthalide and phthalane derivatives, isolated as antimicrobial agents from Emericella sp. IFM57991. |
ジャーナル | J Antibiot (Tokyo) |
Abstract |
Three new phthalide derivatives, emefuranones A1, A2 and B (1-3); six new phthalane derivatives, emefuran A, B1, B2, C1, C2 and D (4-9); three new farnesylated phthalide derivatives, farnesylemefuranones A-C (10-12); xylarinol C (13); and emericelloxide (14), along with four known compounds (dustanin, sorbicillin, aspergillodiol and xylarinol A), were isolated from the culture extracts of Emericella sp. IFM57991. Structures of 1-14 were elucidated on the basis of spectroscopic analysis and chemical evidence. Compounds 4-7 and 13 showed moderate antibacterial activities against Bacillus subtilis. |
巻・号 | 69(2) |
ページ | 89-96 |
公開日 | 2016-2-1 |
DOI | 10.1038/ja.2015.85 |
PII | ja201585 |
PMID | 26306816 |
MeSH | Anti-Infective Agents / chemistry Anti-Infective Agents / isolation & purification Anti-Infective Agents / pharmacology* Bacillus subtilis / drug effects* Benzofurans / chemistry Benzofurans / isolation & purification Benzofurans / pharmacology* Culture Media / chemistry* Disk Diffusion Antimicrobial Tests Emericella / growth & development Emericella / metabolism* Humans Magnetic Resonance Spectroscopy Models, Molecular Molecular Structure Phthalimides / chemistry Phthalimides / isolation & purification Phthalimides / pharmacology* |
IF | 2.668 |
引用数 | 9 |
WOS 分野 | PHARMACOLOGY & PHARMACY BIOTECHNOLOGY & APPLIED MICROBIOLOGY MICROBIOLOGY IMMUNOLOGY |
リソース情報 | |
病原微生物 | IFM 57991 |