RRC ID 40064
著者 Saito T, Itabashi T, Wakana D, Takeda H, Yaguchi T, Kawai K, Hosoe T.
タイトル Isolation and structure elucidation of new phthalide and phthalane derivatives, isolated as antimicrobial agents from Emericella sp. IFM57991.
ジャーナル J Antibiot (Tokyo)
Abstract Three new phthalide derivatives, emefuranones A1, A2 and B (1-3); six new phthalane derivatives, emefuran A, B1, B2, C1, C2 and D (4-9); three new farnesylated phthalide derivatives, farnesylemefuranones A-C (10-12); xylarinol C (13); and emericelloxide (14), along with four known compounds (dustanin, sorbicillin, aspergillodiol and xylarinol A), were isolated from the culture extracts of Emericella sp. IFM57991. Structures of 1-14 were elucidated on the basis of spectroscopic analysis and chemical evidence. Compounds 4-7 and 13 showed moderate antibacterial activities against Bacillus subtilis.
巻・号 69(2)
ページ 89-96
公開日 2016-2-1
DOI 10.1038/ja.2015.85
PII ja201585
PMID 26306816
MeSH Anti-Infective Agents / chemistry Anti-Infective Agents / isolation & purification Anti-Infective Agents / pharmacology* Bacillus subtilis / drug effects* Benzofurans / chemistry Benzofurans / isolation & purification Benzofurans / pharmacology* Culture Media / chemistry* Disk Diffusion Antimicrobial Tests Emericella / growth & development Emericella / metabolism* Humans Magnetic Resonance Spectroscopy Models, Molecular Molecular Structure Phthalimides / chemistry Phthalimides / isolation & purification Phthalimides / pharmacology*
IF 2.668
引用数 9
WOS 分野 PHARMACOLOGY & PHARMACY BIOTECHNOLOGY & APPLIED MICROBIOLOGY MICROBIOLOGY IMMUNOLOGY
リソース情報
病原微生物 IFM 57991