論文 - 詳細
RRC ID | 45532 |
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著者 | Brandt JP, Ringstad N. |
タイトル | Toll-like Receptor Signaling Promotes Development and Function of Sensory Neurons Required for a C. elegans Pathogen-Avoidance Behavior. |
ジャーナル | Curr Biol |
Abstract |
Toll-like receptors (TLRs) play critical roles in innate immunity in many animal species. The sole TLR of C. elegans--TOL-1--is required for a pathogen-avoidance behavior, yet how it promotes this behavior is unknown. We show that for pathogen avoidance TOL-1 signaling is required in the chemosensory BAG neurons, where it regulates gene expression and is necessary for their chemosensory function. Genetic studies revealed that TOL-1 acts together with many conserved components of TLR signaling. BAG neurons are activated by carbon dioxide (CO₂), and we found that this modality is required for pathogen avoidance. TLR signaling can therefore mediate host responses to microbes through an unexpected mechanism: by promoting the development and function of chemosensory neurons that surveil the metabolic activity of environmental microbes. |
巻・号 | 25(17) |
ページ | 2228-37 |
公開日 | 2015-8-31 |
DOI | 10.1016/j.cub.2015.07.037 |
PII | S0960-9822(15)00871-4 |
PMID | 26279230 |
PMC | PMC4642686 |
MeSH | Animals Avoidance Learning Caenorhabditis elegans / genetics* Caenorhabditis elegans / metabolism Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism Carbon Dioxide / metabolism Cues Gene Expression* Nerve Tissue Proteins / genetics Nerve Tissue Proteins / metabolism Sensory Receptor Cells / metabolism Serratia marcescens / physiology* Signal Transduction* |
IF | 9.601 |
引用数 | 43 |
WOS 分野 | BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
リソース情報 | |
線虫 | tm2816 |