RRC ID |
45390
|
著者 |
Yoshida H, Watanabe H, Ishida A, Watanabe W, Narumi K, Atsumi T, Sugita C, Kurokawa M.
|
タイトル |
Naringenin suppresses macrophage infiltration into adipose tissue in an early phase of high-fat diet-induced obesity.
|
ジャーナル |
Biochem Biophys Res Commun
|
Abstract |
Obese adipose tissue is characterized by increased macrophage infiltration, which results in chronic inflammation in adipose tissue and leads to obesity-related diseases such as type 2 diabetes mellitus and atherosclerosis. The regulation of macrophage infiltration into adipose tissue is an important strategy for preventing and treating obesity-related diseases. In this study, we report that naringenin, a citrus flavonoid, suppressed macrophage infiltration into adipose tissue induced by short-term (14 days) feeding of a high-fat diet in mice; although naringenin did not show any differences in high-fat diet-induced changes of serum biochemical parameters in this short administration period. Naringenin suppressed monocyte chemoattractant protein-1 (MCP-1) in adipose tissue, and this effect was mediated in part through inhibition of c-Jun NH2-terminal kinase pathway. Naringenin also inhibited MCP-1 expression in adipocytes, macrophages, and a co-culture of adipocytes and macrophages. Our results suggest a mechanism by which daily consumption of naringenin may exhibit preventive effects on obesity-related diseases.
|
巻・号 |
454(1)
|
ページ |
95-101
|
公開日 |
2014-11-7
|
DOI |
10.1016/j.bbrc.2014.10.038
|
PII |
S0006-291X(14)01836-1
|
PMID |
25450363
|
MeSH |
3T3-L1 Cells
Adipocytes / drug effects
Adipocytes / metabolism
Adipose Tissue / drug effects*
Adipose Tissue / metabolism
Adipose Tissue / pathology*
Animals
Anthracenes / pharmacology
Cell Line
Chemokine CCL2 / biosynthesis
Chemokine CCL2 / genetics
Diabetes Mellitus, Type 2 / prevention & control
Diet, High-Fat / adverse effects*
Flavanones / administration & dosage
Flavanones / pharmacology*
MAP Kinase Signaling System / drug effects
Macrophages / drug effects*
Macrophages / pathology*
Male
Mice
Mice, Inbred C57BL
Obesity / drug therapy*
Obesity / etiology
Obesity / pathology*
RNA, Messenger / genetics
RNA, Messenger / metabolism
Time Factors
|
IF |
2.985
|
引用数 |
24
|
WOS 分野
|
BIOPHYSICS
BIOCHEMISTRY & MOLECULAR BIOLOGY
|
リソース情報 |
ヒト・動物細胞 |
RAW 264(RCB0535) |