| RRC ID |
40005
|
| 著者 |
Romero-Carvajal A, Navajas Acedo J, Jiang L, Kozlovskaja-Gumbrienė A, Alexander R, Li H, Piotrowski T.
|
| タイトル |
Regeneration of Sensory Hair Cells Requires Localized Interactions between the Notch and Wnt Pathways.
|
| ジャーナル |
Dev Cell
|
| Abstract |
In vertebrates, mechano-electrical transduction of sound is accomplished by sensory hair cells. Whereas mammalian hair cells are not replaced when lost, in fish they constantly renew and regenerate after injury. In vivo tracking and cell fate analyses of all dividing cells during lateral line hair cell regeneration revealed that support and hair cell progenitors localize to distinct tissue compartments. Importantly, we find that the balance between self-renewal and differentiation in these compartments is controlled by spatially restricted Notch signaling and its inhibition of Wnt-induced proliferation. The ability to simultaneously study and manipulate individual cell behaviors and multiple pathways in vivo transforms the lateral line into a powerful paradigm to mechanistically dissect sensory organ regeneration. The striking similarities to other vertebrate stem cell compartments uniquely place zebrafish to help elucidate why mammals possess such low capacity to regenerate hair cells.
|
| 巻・号 |
34(3)
|
| ページ |
267-82
|
| 公開日 |
2015-8-10
|
| DOI |
10.1016/j.devcel.2015.05.025
|
| PII |
S1534-5807(15)00361-5
|
| PMID |
26190147
|
| PMC |
PMC4557215
|
| MeSH |
Animals
Cell Differentiation / physiology
Cell Lineage
Cell Proliferation
Cells, Cultured
Hair Cells, Auditory / physiology*
Mechanoreceptors / metabolism
Receptors, Notch / antagonists & inhibitors
Receptors, Notch / metabolism*
Regeneration / physiology*
Stem Cells / cytology
Wnt Proteins / antagonists & inhibitors
Wnt Proteins / metabolism*
Wnt Signaling Pathway / physiology
Zebrafish / embryology*
Zebrafish Proteins / metabolism
|
| IF |
10.092
|
| 引用数 |
43
|
|
WOS 分野
|
DEVELOPMENTAL BIOLOGY
CELL BIOLOGY
|
| リソース情報 |
| ゼブラフィッシュ |
Tg(6xTcf/LefBS-miniP:d2EGFP) |
