論文 - 詳細
RRC ID | 47490 |
---|---|
著者 | Huang J, Feng Y, Chen X, Li W, Xue L. |
タイトル | Myc inhibits JNK-mediated cell death in vivo. |
ジャーナル | Apoptosis |
Abstract |
The proto-oncogene Myc is well known for its roles in promoting cell growth, proliferation and apoptosis. However, in this study, we found from a genetic screen that Myc inhibits, rather than promotes, cell death triggered by c-Jun N-terminal kinase (JNK) signaling in Drosophila. Firstly, expression of Drosophila Myc (dMyc) suppresses, whereas loss of dMyc enhances, ectopically activated JNK signaling-induced cell death. Secondly, dMyc impedes physiologically activated JNK pathway-mediated cell death. Thirdly, loss of dMyc triggers JNK pathway activation and JNK-dependent cell death. Finally, the mammalian cMyc gene, when expressed in Drosophila, impedes activated JNK signaling-induced cell death. Thus, besides its well-studied apoptosis promoting function, Myc also antagonizes JNK-mediated cell death in Drosophila, and this function is likely conserved from fly to human. |
巻・号 | 22(4) |
ページ | 479-490 |
公開日 | 2017-4-1 |
DOI | 10.1007/s10495-016-1340-4 |
PII | 10.1007/s10495-016-1340-4 |
PMID | 28150056 |
MeSH | Animals Apoptosis / genetics* Compound Eye, Arthropod / cytology Compound Eye, Arthropod / embryology Compound Eye, Arthropod / growth & development DNA-Binding Proteins / deficiency DNA-Binding Proteins / genetics DNA-Binding Proteins / physiology* Drosophila Proteins / deficiency Drosophila Proteins / genetics Drosophila Proteins / physiology* Drosophila melanogaster / cytology Drosophila melanogaster / genetics* Female Gene Expression Regulation, Developmental Genes, Synthetic Genes, myc* Humans Larva MAP Kinase Signaling System / genetics* Membrane Proteins / genetics Membrane Proteins / physiology Morphogenesis Protein Isoforms / genetics Protein Isoforms / physiology Proto-Oncogene Mas Proto-Oncogene Proteins c-myc / genetics Proto-Oncogene Proteins c-myc / physiology Recombinant Fusion Proteins / metabolism Species Specificity Thorax / cytology Thorax / embryology Thorax / growth & development Transcription Factors / deficiency Transcription Factors / genetics Transcription Factors / physiology* Wings, Animal / cytology Wings, Animal / embryology Wings, Animal / growth & development |
IF | 4.543 |
引用数 | 4 |
WOS 分野 | BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
リソース情報 | |
ショウジョウバエ | 5680R-2 |