RRC ID |
36309
|
著者 |
Tastekin I, Riedl J, Schilling-Kurz V, Gomez-Marin A, Truman JW, Louis M.
|
タイトル |
Role of the subesophageal zone in sensorimotor control of orientation in Drosophila larva.
|
ジャーナル |
Curr Biol
|
Abstract |
Chemotaxis is a powerful paradigm to investigate how nervous systems represent and integrate changes in sensory signals to direct navigational decisions. In the Drosophila melanogaster larva, chemotaxis mainly consists of an alternation of distinct behavioral modes: runs and directed turns. During locomotion, turns are triggered by the integration of temporal changes in the intensity of the stimulus. Upon completion of a turning maneuver, the direction of motion is typically realigned toward the odor gradient. While the anatomy of the peripheral olfactory circuits and the locomotor system of the larva are reasonably well documented, the neural circuits connecting the sensory neurons to the motor neurons remain unknown. We combined a loss-of-function behavioral screen with optogenetics-based clonal gain-of-function manipulations to identify neurons that are necessary and sufficient for the initiation of reorientation maneuvers in odor gradients. Our results indicate that a small subset of neurons residing in the subesophageal zone controls the rate of transition from runs to turns-a premotor function compatible with previous observations made in other invertebrates. After having shown that this function pertains to the processing of inputs from different sensory modalities (olfaction, vision, thermosensation), we conclude that the subesophageal zone operates as a general premotor center that regulates the selection of different behavioral programs based on the integration of sensory stimuli. The present analysis paves the way for a systematic investigation of the neural computations underlying action selection in a miniature brain amenable to genetic manipulations.
|
巻・号 |
25(11)
|
ページ |
1448-60
|
公開日 |
2015-6-1
|
DOI |
10.1016/j.cub.2015.04.016
|
PII |
S0960-9822(15)00429-7
|
PMID |
25959970
|
MeSH |
Animals
Drosophila / physiology*
Feedback, Sensory*
Female
Larva / physiology
Male
Neurons / physiology*
Orientation / physiology*
Phenotype
|
IF |
9.601
|
引用数 |
26
|
WOS 分野
|
BIOCHEMISTRY & MOLECULAR BIOLOGY
CELL BIOLOGY
|
リソース情報 |
ショウジョウバエ |
DGRC#103747
DGRC#103786
DGRC#103813
DGRC#103963
DGRC#104060
DGRC#104104
DGRC#104237
DGRC#104511
DGRC#104553
DGRC#104798
DGRC#104870
DGRC#104941
DGRC#105201
DGRC#112697
DGRC#112896
DGRC#112972
DGRC#113094
DGRC#113495
DGRC#113606
DGRC#113885
DGRC#113938
DGRC#114247
DGRC#114253
DGRC#114255
over 1
100 P[GAL4] enhancer trap lines (NP-GAL4) |