RRC ID 36358
著者 Ishii M, Matsumoto Y, Sekimizu K.
タイトル Usefulness of silkworm as a model animal for understanding the molecular mechanisms of fungal pathogenicity.
ジャーナル Drug Discov Ther
Abstract Candida albicans, Candida tropicalis, Candida grabrata, and Cryptococcus neoformans are causative pathogens of opportunistic diseases in immunocompromised human patients. Silkworms are killed by injection of these pathogenic fungi into their hemolymph. In this paper, we describe recent results by our laboratory and other researchers using gene-deficient strains of these pathogenic fungi. The silkworm is considered to be a useful model animal for understanding the pathogenicity of these fungi. Silkworms are also beneficial for evaluating therapeutically active anti-fungal reagents.
巻・号 9(4)
ページ 234-7
公開日 2015-8-1
DOI 10.5582/ddt.2015.01052
PMID 26370522
MeSH Animals Bombyx / microbiology* Candida / drug effects Candida / genetics Candida / pathogenicity* Cryptococcus neoformans / drug effects Cryptococcus neoformans / genetics Cryptococcus neoformans / pathogenicity* Disease Models, Animal Humans Virulence / genetics
引用数 7
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