RRC ID 45568
著者 Govindan JA, Jayamani E, Zhang X, Breen P, Larkins-Ford J, Mylonakis E, Ruvkun G.
タイトル Lipid signalling couples translational surveillance to systemic detoxification in Caenorhabditis elegans.
ジャーナル Nat Cell Biol
Abstract Translation in eukaryotes is followed to detect toxins and virulence factors and coupled to the induction of defence pathways. Caenorhabditis elegans germline-specific mutations in translation components are detected by this system to induce detoxification and immune responses in distinct somatic cells. An RNA interference screen revealed gene inactivations that act at multiple steps in lipid biosynthetic and kinase pathways upstream of MAP kinase to mediate the systemic communication of translation defects to induce detoxification genes. Mammalian bile acids can rescue the defect in detoxification gene induction caused by C. elegans lipid biosynthetic gene inactivations. Extracts prepared from C. elegans with translation deficits but not from the wild type can also rescue detoxification gene induction in lipid-biosynthesis-defective strains. These eukaryotic antibacterial countermeasures are not ignored by bacteria: particular bacterial species suppress normal C. elegans detoxification responses to mutations in translation factors.
巻・号 17(10)
ページ 1294-303
公開日 2015-10-1
DOI 10.1038/ncb3229
PII ncb3229
PMID 26322678
PMC PMC4589496
MeSH Animals Animals, Genetically Modified Bacteria / immunology Biosynthetic Pathways / genetics Caenorhabditis elegans / genetics Caenorhabditis elegans / immunology* Caenorhabditis elegans / metabolism Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / immunology* Caenorhabditis elegans Proteins / metabolism Germ-Line Mutation Green Fluorescent Proteins / genetics Green Fluorescent Proteins / metabolism Immunity, Innate / genetics Immunity, Innate / immunology* Lipids / biosynthesis* MAP Kinase Signaling System / genetics MAP Kinase Signaling System / immunology Microscopy, Fluorescence Polysaccharides, Bacterial / immunology Protein Biosynthesis / genetics RNA Interference / immunology Signal Transduction / genetics Signal Transduction / immunology* Xenobiotics / immunology Xenobiotics / metabolism
IF 20.042
引用数 9
WOS 分野 CELL BIOLOGY
リソース情報
線虫 tm483