論文 - 詳細
RRC ID | 33616 |
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著者 | Wada H, Iwasaki M, Kawakami K. |
タイトル | Development of the lateral line canal system through a bone remodeling process in zebrafish. |
ジャーナル | Dev Biol |
Abstract |
The lateral line system of teleost fish is composed of mechanosensory receptors (neuromasts), comprising superficial receptors and others embedded in canals running under the skin. Canal diameter and size of the canal neuromasts are correlated with increasing body size, thus providing a very simple system to investigate mechanisms underlying the coordination between organ growth and body size. Here, we examine the development of the trunk lateral line canal system in zebrafish. We demonstrated that trunk canals originate from scales through a bone remodeling process, which we suggest is essential for the normal growth of canals and canal neuromasts. Moreover, we found that lateral line cells are required for the formation of canals, suggesting the existence of mutual interactions between the sensory system and surrounding connective tissues. |
巻・号 | 392(1) |
ページ | 1-14 |
公開日 | 2014-8-1 |
DOI | 10.1016/j.ydbio.2014.05.004 |
PII | S0012-1606(14)00248-6 |
PMID | 24836859 |
MeSH | Alkaline Phosphatase / biosynthesis Alkaline Phosphatase / metabolism Animals Animals, Genetically Modified Bone Remodeling / physiology* Bone and Bones / embryology Embryonic Development Integumentary System Intercellular Signaling Peptides and Proteins / genetics Intercellular Signaling Peptides and Proteins / metabolism Lateral Line System / cytology* Lateral Line System / embryology* Osteoblasts / metabolism Osteoclasts / metabolism Receptor, Macrophage Colony-Stimulating Factor / genetics Sp7 Transcription Factor Transcription Factors / biosynthesis Wnt Signaling Pathway Zebrafish / embryology* Zebrafish Proteins / biosynthesis Zebrafish Proteins / genetics Zebrafish Proteins / metabolism |
IF | 2.896 |
引用数 | 22 |
WOS 分野 | DEVELOPMENTAL BIOLOGY |
リソース情報 | |
ゼブラフィッシュ | Tg[atoh1a:dTomato] SAGFF(LF)228A |