RRC ID 36301
著者 Pradhan-Sundd T, Verheyen EM.
タイトル The role of Bro1- domain-containing protein Myopic in endosomal trafficking of Wnt/Wingless.
ジャーナル Dev Biol
Abstract Wingless (Wg) proteins are secreted-lipid-modified glycoproteins involved in tissue patterning and cell-fate specification. Wg secretion is regulated by a specialized mechanism involving a repertoire of proteins including Wntless (Wls). Here, we show that the Bro1-domain-containing protein Myopic (Mop) is indispensable for endosomal trafficking of Wg and Wls. Reductions in Mop leads to trapping of Wg and Wls in the early endosomes. Overexpression of the endosomal sorting protein Hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs) rescues the trafficking defect caused by the mop loss of function. The vertebrate homolog of Mop, Histidine domain-containing protein tyrosine phosphatase (HDPTP), was also found to have a conserved role in Wnt trafficking. Our study highlights the importance of early endosomal trafficking for Wg secretion, and identifies a novel role for Mop in Wg signaling.
巻・号 392(1)
ページ 93-107
公開日 2014-8-1
DOI 10.1016/j.ydbio.2014.04.019
PII S0012-1606(14)00237-1
PMID 24821423
MeSH Animals Cells, Cultured Drosophila Proteins / genetics Drosophila Proteins / metabolism* Drosophila melanogaster / genetics Drosophila melanogaster / metabolism* Endocytosis / genetics* Endosomes / metabolism Glyceraldehyde-3-Phosphate Dehydrogenases / genetics Intracellular Signaling Peptides and Proteins / genetics Protein Structure, Tertiary Protein Transport / genetics Protein Tyrosine Phosphatases / genetics Protein Tyrosine Phosphatases / metabolism* RNA Interference RNA, Small Interfering Wnt Proteins / metabolism Wnt Signaling Pathway / genetics Wnt1 Protein / genetics Wnt1 Protein / metabolism*
IF 2.896
引用数 7
WOS 分野 DEVELOPMENTAL BIOLOGY
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