RRC ID 46043
著者 Lee JY, Kim C, Kim J, Park C.
タイトル DJR-1.2 of Caenorhabditis elegans is induced by DAF-16 in the dauer state.
ジャーナル Gene
Abstract Caenorhabditis elegans DJR-1.2, a homolog of human DJ-1, has recently been demonstrated to be a novel glyoxalase and protects worms against glyoxals. Here, we report that expression of DJR-1.2 is substantially increased during starvation as well as in the dauer stage. The induction of DJR-1.2 led to increased glyoxalase activity in the dauer state, thereby increasing protection against glyoxals. The induction is regulated by DAF-16, a transcriptional regulator implicated in oxidative stress and normal lifespan.
巻・号 524(2)
ページ 373-6
公開日 2013-7-25
DOI 10.1016/j.gene.2013.04.032
PII S0378-1119(13)00484-8
PMID 23624124
MeSH Aldehyde Oxidoreductases / genetics Aldehyde Oxidoreductases / metabolism* Animals Animals, Genetically Modified / genetics Animals, Genetically Modified / metabolism Caenorhabditis elegans / drug effects Caenorhabditis elegans / genetics Caenorhabditis elegans / metabolism* Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism* Enzyme Activation Food Deprivation Forkhead Transcription Factors Gene Expression Regulation, Enzymologic* Glyoxal / pharmacology Gonads / drug effects Gonads / metabolism Oxidative Stress Survival Analysis Transcription Factors / genetics Transcription Factors / metabolism* Transcription, Genetic
IF 2.984
引用数 6
WOS 分野 GENETICS & HEREDITY
リソース情報
線虫 tm918 tm1346