RRC ID 47275
著者 Nitta Y, Yamazaki D, Sugie A, Hiroi M, Tabata T.
タイトル DISCO Interacting Protein 2 regulates axonal bifurcation and guidance of Drosophila mushroom body neurons.
ジャーナル Dev Biol
Abstract Axonal branching is one of the key processes within the enormous complexity of the nervous system to enable a single neuron to send information to multiple targets. However, the molecular mechanisms that control branch formation are poorly understood. In particular, previous studies have rarely addressed the mechanisms underlying axonal bifurcation, in which axons form new branches via splitting of the growth cone. We demonstrate that DISCO Interacting Protein 2 (DIP2) is required for precise axonal bifurcation in Drosophila mushroom body (MB) neurons by suppressing ectopic bifurcation and regulating the guidance of sister axons. We also found that DIP2 localize to the plasma membrane. Domain function analysis revealed that the AMP-synthetase domains of DIP2 are essential for its function, which may involve exerting a catalytic activity that modifies fatty acids. Genetic analysis and subsequent biochemical analysis suggested that DIP2 is involved in the fatty acid metabolization of acyl-CoA. Taken together, our results reveal a function of DIP2 in the developing nervous system and provide a potential functional relationship between fatty acid metabolism and axon morphogenesis.
巻・号 421(2)
ページ 233-244
公開日 2017-1-15
DOI 10.1016/j.ydbio.2016.11.015
PII S0012-1606(16)30366-9
PMID 27908785
MeSH Animals Animals, Genetically Modified Axon Guidance* Axons / metabolism* Clone Cells Drosophila Proteins / chemistry Drosophila Proteins / genetics Drosophila Proteins / metabolism* Drosophila melanogaster / metabolism* Fatty Acids / metabolism Lipid Metabolism Models, Biological Mushroom Bodies / innervation* Mushroom Bodies / metabolism* Mutation / genetics Nerve Tissue Proteins / chemistry Nerve Tissue Proteins / genetics Nerve Tissue Proteins / metabolism* Protein Domains RNA Interference Sequence Deletion Sequence Homology, Amino Acid
IF 2.896
引用数 7
WOS 分野 DEVELOPMENTAL BIOLOGY
リソース情報
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