RRC ID 47311
著者 Yang HJ, Osakada H, Kojidani T, Haraguchi T, Hiraoka Y.
タイトル Lipid droplet dynamics during Schizosaccharomyces pombe sporulation and their role in spore survival.
ジャーナル Biol Open
Abstract Upon nitrogen starvation, the fission yeast Schizosaccharomyces pombe forms dormant spores; however, the mechanisms by which a spore sustains life without access to exogenous nutrients remain unclear. Lipid droplets are reservoirs of neutral lipids that act as important cellular energy resources. Using live-cell imaging analysis, we found that the lipid droplets of mother cells redistribute to their nascent spores. Notably, this process was actin polymerization-dependent and facilitated by the leading edge proteins of the forespore membrane. Spores lacking triacylglycerol synthesis, which is essential for lipid droplet formation, failed to germinate. Our results suggest that the lipid droplets are important for the sustenance of life in spores.
巻・号 6(2)
ページ 217-222
公開日 2017-2-15
DOI 10.1242/bio.022384
PII bio.022384
PMID 28011631
PMC PMC5312105
IF 2.029
引用数 2
WOS 分野 BIOLOGY
リソース情報
酵母 FY16412 FY17842 FY12290