RRC ID 47423
著者 Hayashi M, Shinozuka Y, Shigenobu S, Sato M, Sugimoto M, Ito S, Abe K, Kobayashi S.
タイトル Conserved role of Ovo in germline development in mouse and Drosophila.
ジャーナル Sci Rep
Abstract Ovo, which encodes a transcription factor with Zn-finger domains, is evolutionarily conserved among animals. In Drosophila, in addition to its zygotic function for egg production, maternal ovo activity is required in primordial germ cells (PGCs) for expression of germline genes such as vasa and nanos. In this study, we found that maternal Ovo accumulates in PGC nuclei during embryogenesis. In these cells, ovo serves a dual function: activation of genes expressed predominantly in PGCs, and conversely suppression of somatic genes. Reduction of ovo activity in PGCs makes them unable to develop normally into germ cells of both sexes. In mice, knockout of the ovo ortholog, Ovol2, which is expressed in PGCs, decreases the number of PGCs during early embryogenesis. These data strongly suggest that ovo acts as part of an evolutionarily conserved mechanism that regulates germline development in animals.
巻・号 7
ページ 40056
公開日 2017-1-6
DOI 10.1038/srep40056
PII srep40056
PMID 28059165
PMC PMC5216385
MeSH Animals Cell Differentiation* DNA-Binding Proteins / genetics DNA-Binding Proteins / metabolism* Drosophila Drosophila Proteins / genetics Drosophila Proteins / metabolism* Embryonic Development* Germ Cells / physiology* Mice Mice, Knockout Transcription Factors / genetics Transcription Factors / metabolism*
IF 3.998
引用数 12
WOS 分野 DEVELOPMENTAL BIOLOGY
リソース情報
ショウジョウバエ CAS-0004 TBX-0002