RRC ID 45907
著者 Zou CG, Ma YC, Dai LL, Zhang KQ.
タイトル Autophagy protects C. elegans against necrosis during Pseudomonas aeruginosa infection.
ジャーナル Proc Natl Acad Sci U S A
Abstract Autophagy, a conserved pathway that delivers intracellular materials into lysosomes for degradation, is involved in development, aging, and a variety of diseases. Accumulating evidence demonstrates that autophagy plays a protective role against infectious diseases by diminishing intracellular pathogens, including bacteria, viruses, and parasites. However, the mechanism by which autophagy regulates innate immunity remains largely unknown. Here, we show that autophagy is involved in host defense against a pathogenic bacterium Pseudomonas aeruginosa in the metazoan Caenorhabditis elegans. P. aeruginosa infection induces autophagy via a conserved extracellular signal-regulated kinase (ERK). Intriguingly, impairment of autophagy does not influence the intestinal accumulation of P. aeruginosa, but instead induces intestinal necrosis. Inhibition of necrosis results in the survival of autophagy-deficient worms after P. aeruginosa infection. These findings reveal a previously unidentified role for autophagy in protection against necrosis triggered by pathogenic bacteria in C. elegans and implicate that such a function of autophagy may be conserved through the inflammatory response in diverse organisms.
巻・号 111(34)
ページ 12480-5
公開日 2014-8-26
DOI 10.1073/pnas.1405032111
PII 1405032111
PMID 25114220
PMC PMC4151725
MeSH Animals Autophagy / genetics Autophagy / immunology* Caenorhabditis elegans / genetics Caenorhabditis elegans / immunology* Caenorhabditis elegans / microbiology Gene Knockdown Techniques Genes, Helminth Host-Pathogen Interactions / immunology Immunity, Innate / genetics MAP Kinase Signaling System / immunology Mutation Necrosis Pseudomonas Infections / immunology* Pseudomonas Infections / pathology Pseudomonas aeruginosa / immunology RNA Interference
IF 9.412
引用数 28
WOS 分野 CELL BIOLOGY
リソース情報
線虫 tm544 tm659