RRC ID 37115
著者 Therrien M, Rouleau GA, Dion PA, Parker JA.
タイトル FET proteins regulate lifespan and neuronal integrity.
ジャーナル Sci Rep
Abstract The FET protein family includes FUS, EWS and TAF15 proteins, all of which have been linked to amyotrophic lateral sclerosis, a fatal neurodegenerative disease affecting motor neurons. Here, we show that a reduction of FET proteins in the nematode Caenorhabditis elegans causes synaptic dysfunction accompanied by impaired motor phenotypes. FET proteins are also involved in the regulation of lifespan and stress resistance, acting partially through the insulin/IGF-signalling pathway. We propose that FET proteins are involved in the maintenance of lifespan, cellular stress resistance and neuronal integrity.
巻・号 6
ページ 25159
公開日 2016-4-27
DOI 10.1038/srep25159
PII srep25159
PMID 27117089
PMC PMC4846834
MeSH Animals Astemizole Caenorhabditis elegans / genetics Caenorhabditis elegans / metabolism* Caenorhabditis elegans Proteins / genetics* Caenorhabditis elegans Proteins / metabolism* Insulin / metabolism Longevity* Mutation Neurons / metabolism* Signal Transduction Somatomedins / metabolism Stress, Physiological
IF 3.998
引用数 3
WOS 分野 BIOCHEMISTRY & MOLECULAR BIOLOGY
リソース情報
線虫 tm4439