論文 - 詳細
RRC ID | 33618 |
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著者 | Maier EC, Saxena A, Alsina B, Bronner ME, Whitfield TT. |
タイトル | Sensational placodes: neurogenesis in the otic and olfactory systems. |
ジャーナル | Dev Biol |
Abstract |
For both the intricate morphogenetic layout of the sensory cells in the ear and the elegantly radial arrangement of the sensory neurons in the nose, numerous signaling molecules and genetic determinants are required in concert to generate these specialized neuronal populations that help connect us to our environment. In this review, we outline many of the proteins and pathways that play essential roles in the differentiation of otic and olfactory neurons and their integration into their non-neuronal support structures. In both cases, well-known signaling pathways together with region-specific factors transform thickened ectodermal placodes into complex sense organs containing numerous, diverse neuronal subtypes. Olfactory and otic placodes, in combination with migratory neural crest stem cells, generate highly specialized subtypes of neuronal cells that sense sound, position and movement in space, odors and pheromones throughout our lives. |
巻・号 | 389(1) |
ページ | 50-67 |
公開日 | 2014-5-1 |
DOI | 10.1016/j.ydbio.2014.01.023 |
PII | S0012-1606(14)00051-7 |
PMID | 24508480 |
PMC | PMC3988839 |
MeSH | Animals Cell Differentiation / genetics Cell Differentiation / physiology Ear, Inner / cytology Ear, Inner / embryology* Ear, Inner / metabolism Ectoderm / cytology Ectoderm / embryology* Ectoderm / metabolism Gene Expression Regulation, Developmental Humans Neurogenesis / genetics Neurogenesis / physiology* Olfactory Pathways / cytology Olfactory Pathways / embryology* Olfactory Pathways / metabolism Sense Organs / cytology Sense Organs / embryology* Sense Organs / metabolism Sensory Receptor Cells / cytology Sensory Receptor Cells / metabolism |
IF | 2.896 |
引用数 | 27 |
WOS 分野 | DEVELOPMENTAL BIOLOGY |
リソース情報 | |
ゼブラフィッシュ | Tg(OMP2k:lyn-mRFP)/rw035 Tg(TRPC24.5k:gap-Venus)/rw037 |