RRC ID |
11049
|
著者 |
Sakudoh T, Nakashima T, Kuroki Y, Fujiyama A, Kohara Y, Honda N, Fujimoto H, Shimada T, Nakagaki M, Banno Y, Tsuchida K.
|
タイトル |
Diversity in copy number and structure of a silkworm morphogenetic gene as a result of domestication.
|
ジャーナル |
Genetics
|
Abstract |
The carotenoid-binding protein (CBP) of the domesticated silkworm, Bombyx mori, a major determinant of cocoon color, is likely to have been substantially influenced by domestication of this species. We analyzed the structure of the CBP gene in multiple strains of B. mori, in multiple individuals of the wild silkworm, B. mandarina (the putative wild ancestor of B. mori), and in a number of other lepidopterans. We found the CBP gene copy number in genomic DNA to vary widely among B. mori strains, ranging from 1 to 20. The copies of CBP are of several types, based on the presence of a retrotransposon or partial deletion of the coding sequence. In contrast to B. mori, B. mandarina was found to possess a single copy of CBP without the retrotransposon insertion, regardless of habitat. Several other lepidopterans were found to contain sequences homologous to CBP, revealing that this gene is evolutionarily conserved in the lepidopteran lineage. Thus, domestication can generate significant diversity of gene copy number and structure over a relatively short evolutionary time.
|
巻・号 |
187(3)
|
ページ |
965-76
|
公開日 |
2011-3-1
|
DOI |
10.1534/genetics.110.124982
|
PII |
genetics.110.124982
|
解説 |
Y(黄血)の原因遺伝子はCBPである。CBPはカロテノイド結合タンパク質をコードする。p50系統(+Y/+Y)では、CBPのエクソン2が完全に欠失している。
|
PMID |
21242537
|
PMC |
PMC3063685
|
MeSH |
Amino Acid Sequence
Animals
Base Sequence
Bombyx / genetics*
Bombyx / growth & development*
Carotenoids / metabolism*
Carrier Proteins / genetics
Evolution, Molecular
Gene Dosage*
Gene Expression / genetics
Genetic Variation*
Insect Proteins / classification
Insect Proteins / genetics*
Insect Proteins / metabolism
Molecular Sequence Data
Morphogenesis / genetics*
Phylogeny
Retroelements / genetics
Sequence Deletion
|
IF |
4.015
|
引用数 |
15
|
WOS 分野
|
GENETICS & HEREDITY
|
リソース情報 |
カイコ |
Samia cynthia ricini
Samia cynthia pryeri
Antheraea pernyi
Antheraea yamamai
b10
c04
c05
c10
c11
c12
c15
c21
c23
c44
e09
n16
p22
p50
w06 |