| RRC ID |
12179
|
| 著者 |
Miyazaki M, Takemura N, Watanabe S, Hata N, Misawa Y, Okuyama H.
|
| タイトル |
Dietary docosahexaenoic acid ameliorates, but rapeseed oil and safflower oil accelerate renal injury in stroke-prone spontaneously hypertensive rats as compared with soybean oil, which is associated with expression for renal transforming growth factor-beta, fibronectin and renin.
|
| ジャーナル |
Biochim Biophys Acta
|
| Abstract |
We have noted that n-3 fatty acid-rich oils, such as fish oil, perilla oil and flaxseed oil as well as ethyl docosahexaenoate (DHA) prolonged the survival time of stroke-prone spontaneously hypertensive rats (SHRSP) rats by approximately 10% as compared with linoleate (n-6)-rich safflower oil. Rapeseed oil with a relatively low n-6/n-3 ratio unusually shortened the survival time by approximately 40%, suggesting the presence of minor components unfavorable to SHRSP rats. This study examined the effects of dietary oils and DHA on renal injury and gene expression related to renal injury in SHRSP rats. Rats fed rapeseed oil- and safflower oil-supplemented diets developed more severe proteinuria than those fed soybean oil-supplemented diet used as a control, but there were no significant differences in blood pressure. In contrast, the DHA-supplemented diet inhibited the development of proteinuria and suppressed hypertension. The mRNA levels for renal TGF-beta, fibronectin and renin were higher in the rapeseed oil and safflower oil groups after 9 weeks of feeding of the experimental diet than in the soybean oil and DHA groups. The fatty acid composition of kidney phospholipids was markedly affected by these diets. These results indicate that the renal injury observed in the groups fed safflower oil with a high n-6/n-3 ratio and rapeseed oil with presumed minor components is accompanied by increased expression of the TGF-beta, renin and fibronectin genes, and that dietary DHA suppresses renal injury and gene expression as compared with soybean oil.
|
| 巻・号 |
1483(1)
|
| ページ |
101-10
|
| 公開日 |
2000-1-3
|
| DOI |
10.1016/s1388-1981(99)00180-8
|
| PII |
S1388-1981(99)00180-8
|
| PMID |
10601699
|
| MeSH |
Animals
Blood Pressure
Dietary Fats / pharmacology*
Dietary Fats, Unsaturated / pharmacology*
Docosahexaenoic Acids / pharmacology*
Fatty Acids / analysis
Fatty Acids, Monounsaturated
Fibronectins / genetics
Fibronectins / metabolism
Gene Expression
Heart Rate
Kidney / drug effects*
Kidney / physiopathology
Phospholipids / metabolism
Plant Oils / pharmacology
RNA, Messenger / metabolism
Rapeseed Oil
Rats
Rats, Inbred SHR
Renin / genetics
Renin / metabolism
Safflower Oil / pharmacology
Soybean Oil / pharmacology
Stroke / physiopathology*
Time Factors
Transforming Growth Factor beta / genetics
Transforming Growth Factor beta / metabolism
|
| IF |
3.411
|
| 引用数 |
23
|
|
WOS 分野
|
BIOPHYSICS
BIOCHEMISTRY & MOLECULAR BIOLOGY
CELL BIOLOGY
|
| リソース情報 |
| 遺伝子材料 |
pTGF-11 (RDB01195) |
