RRC ID |
12187
|
著者 |
Nakamura T, Akiyoshi H, Shiota G, Isono M, Nakamura K, Moriyama M, Sato K.
|
タイトル |
Hepatoprotective action of adenovirus-transferred HNF-3gamma gene in acute liver injury caused by CCl(4).
|
ジャーナル |
FEBS Lett
|
Abstract |
Hepatocyte nuclear factor-3gamma (HNF-3gamma) is an important regulator of liver-specific genes and the expression of this factor is reduced in the liver injured by carbon tetrachloride (CCl(4)). Wistar rats were infected with a recombinant adenovirus carrying the cDNA for HNF-3gamma (AxCAHNF3gamma) via the tail vein and were treated with CCl(4) by intraperitoneal injection. Liver damage, such as swelling of the hepatocytes and increases in serum marker enzymes were markedly alleviated by AxCAHNF3gamma infection. Interestingly, hepatocyte growth factor (HGF) was strongly induced in the AxCAHNF3gamma-infected liver. Likewise, HNF-1alpha and HNF-1beta levels were increased, but HNF-3alpha and HNF-3beta levels were depressed in the liver. Our results suggest that the transduced HNF-3gamma gene leads to a hepatoprotective effect via the induction of HGF by the combined actions of liver-enriched transcription factors.
|
巻・号 |
459(1)
|
ページ |
1-4
|
公開日 |
1999-10-1
|
DOI |
10.1016/s0014-5793(99)01202-8
|
PII |
S0014-5793(99)01202-8
|
PMID |
10508906
|
MeSH |
Acute Disease
Adenoviridae / genetics
Animals
Carbon Tetrachloride / toxicity*
Chemical and Drug Induced Liver Injury / genetics
Chemical and Drug Induced Liver Injury / metabolism
Chemical and Drug Induced Liver Injury / prevention & control*
DNA-Binding Proteins / biosynthesis
DNA-Binding Proteins / genetics
DNA-Binding Proteins / physiology*
DNA-Binding Proteins / therapeutic use
Gene Expression Regulation / drug effects
Gene Transfer Techniques
Genetic Vectors
Hepatocyte Growth Factor / biosynthesis
Hepatocyte Nuclear Factor 3-gamma
Liver / drug effects
Liver / physiology*
Male
Nuclear Proteins / biosynthesis
Nuclear Proteins / genetics
Nuclear Proteins / physiology*
Nuclear Proteins / therapeutic use
Protective Agents / therapeutic use
Rats
Rats, Wistar
Transcription Factors / biosynthesis
|
IF |
3.057
|
引用数 |
10
|
WOS 分野
|
BIOPHYSICS
BIOCHEMISTRY & MOLECULAR BIOLOGY
CELL BIOLOGY
|
リソース情報 |
遺伝子材料 |
AxCALacZ Adex1CAlacZ (RDB02726) |