論文 - 詳細
| RRC ID | 12750 |
|---|---|
| 著者 | Miura K, Okada Y, Aoi T, Okada A, Takahashi K, Okita K, Nakagawa M, Koyanagi M, Tanabe K, Ohnuki M, Ogawa D, Ikeda E, Okano H, Yamanaka S. |
| タイトル | Variation in the safety of induced pluripotent stem cell lines. |
| ジャーナル | Nat Biotechnol |
| Abstract |
We evaluated the teratoma-forming propensity of secondary neurospheres (SNS) generated from 36 mouse induced pluripotent stem (iPS) cell lines derived in 11 different ways. Teratoma-formation of SNS from embryonic fibroblast-derived iPS cells was similar to that of SNS from embryonic stem (ES) cells. In contrast, SNS from iPS cells derived from different adult tissues varied substantially in their teratoma-forming propensity, which correlated with the persistence of undifferentiated cells. |
| 巻・号 | 27(8) |
| ページ | 743-5 |
| 公開日 | 2009-8-1 |
| DOI | 10.1038/nbt.1554 |
| PII | nbt.1554 |
| PMID | 19590502 |
| MeSH | Animals Cell Line Cell Transformation, Neoplastic / pathology Mice Neurons / cytology Pluripotent Stem Cells / cytology* Safety* Teratoma / pathology |
| IF | 36.553 |
| 引用数 | 591 |
| WOS 分野 | BIOTECHNOLOGY & APPLIED MICROBIOLOGY |
| リソース情報 | |
| 遺伝子材料 | CSII-EF-MCS-IRES2-Venus (RDB04384) pCAG-HIVgp (RDB04394) pCMV-VSV-G-RSV-Rev (RDB04393) |