論文 - 詳細
| RRC ID | 28444 |
|---|---|
| 著者 | Nose A, Nagafuchi A, Takeichi M. |
| タイトル | Isolation of placental cadherin cDNA: identification of a novel gene family of cell-cell adhesion molecules. |
| ジャーナル | EMBO J |
| Abstract |
Ca2+-dependent cell--cell adhesion molecules, termed cadherins, are classified into subclasses with different tissue distributions and distinct cell--cell binding specificities. We report the cloning of cDNA encoding a cadherin present in the placenta which is called P-cadherin. The deduced sequence encodes a polypeptide of 822 amino acids with the characteristic features of integral membrane proteins. A computer search of the amino acid sequence homology of P-cadherin against itself showed that this molecule contains internal repeats in the extracellular domain. Comparison of the primary structure of P-cadherin with that of the epithelial cadherin (E-cadherin) showed that there is 58% homology in their amino acid sequences. These results provide evidence for our hypothesis that cadherins constitute a gene family. |
| 巻・号 | 6(12) |
| ページ | 3655-61 |
| 公開日 | 1987-12-1 |
| DOI | 10.1002/j.1460-2075.1987.tb02698.x |
| PMID | 3428270 |
| PMC | PMC553834 |
| MeSH | Amino Acid Sequence Animals Antigens, Surface* / genetics* Base Sequence Calcium-Binding Proteins / genetics* Cell Adhesion* Cell Adhesion Molecules Cloning, Molecular* DNA / isolation & purification* Female Genes* Mice Mice, Inbred ICR Molecular Sequence Data Nucleic Acid Hybridization Placenta / metabolism* Pregnancy |
| IF | 9.889 |
| 引用数 | 179 |
| WOS 分野 | BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
| リソース情報 | |
| 遺伝子材料 | Mouse P-cadherin full length cDNA (RDB01185). |