| RRC ID |
28961
|
| 著者 |
Kopachik W, Oohata A, Dhokia B, Brookman JJ, Kay RR.
|
| タイトル |
Dictyostelium mutants lacking DIF, a putative morphogen.
|
| ジャーナル |
Cell
|
| Abstract |
DIF is an endogenous extracellular signal that may control differentiation of D. discoideum cells. It is a dialyzable, lipid-like factor that induces stalk cell formation among isolated amebae incubated in vitro with cAMP. To examine the consequences of DIF deprivation, we have isolated several mutant strains that are impaired in DIF accumulation, and whose inability to make stalk cells in vitro and during normal development on agar can be corrected by the addition of exogenous DIF. Little DIF is made by the mutants, and morphological development on agar stops after the cells have aggregated, but before a slug forms. In these DIF-deprived conditions, prespore cells can differentiate, but prestalk cells cannot.
|
| 巻・号 |
33(2)
|
| ページ |
397-403
|
| 公開日 |
1983-6-1
|
| DOI |
10.1016/0092-8674(83)90421-x
|
| PII |
0092-8674(83)90421-X
|
| PMID |
6861203
|
| MeSH |
Cell Differentiation*
Dictyostelium / genetics*
Dictyostelium / growth & development
Morphogenesis
Mutation*
|
| IF |
38.637
|
| 引用数 |
108
|
|
WOS 分野
|
BIOCHEMISTRY & MOLECULAR BIOLOGY
CELL BIOLOGY
|
| リソース情報 |
| 細胞性粘菌 |
S90256
S90425 |
