| RRC ID |
28968
|
| 著者 |
Harwood AJ, Plyte SE, Woodgett J, Strutt H, Kay RR.
|
| タイトル |
Glycogen synthase kinase 3 regulates cell fate in Dictyostelium.
|
| ジャーナル |
Cell
|
| Abstract |
Extracellular cyclic AMP (cAMP) induces the formation of prespore cells in Dictyostelium but inhibits stalk cell formation. We have cloned gskA, which encodes the Dictyostelium homolog of glycogen synthase kinase 3 (GSK-3), and discovered that it is required for both cAMP effects. Disruption of gskA creates a mutant that aggregates but forms few spores and an abnormally high number of stalk cells. These stalk cells probably arise from an expanded prestalk B (pstB) cell population, which normally produces the basal disc of the fruiting body. In cultured mutant cells, cAMP neither inhibits pstB cell differentiation nor induces efficient prespore cell differentiation. We propose that cAMP acts through a common pathway that requires GSK-3 and determines the proportion of prespore and pstB cells.
|
| 巻・号 |
80(1)
|
| ページ |
139-48
|
| 公開日 |
1995-1-13
|
| DOI |
10.1016/0092-8674(95)90458-1
|
| PII |
0092-8674(95)90458-1
|
| PMID |
7813009
|
| MeSH |
Amino Acid Sequence
Animals
Base Sequence
Calcium-Calmodulin-Dependent Protein Kinases / chemistry
Calcium-Calmodulin-Dependent Protein Kinases / genetics
Calcium-Calmodulin-Dependent Protein Kinases / metabolism*
Cell Differentiation
Cyclic AMP / pharmacology
Dictyostelium / cytology*
Dictyostelium / enzymology*
Dictyostelium / genetics
Dictyostelium / physiology
Extracellular Matrix Proteins / genetics
Fungal Proteins / genetics
Genes, Fungal
Glycogen Synthase Kinase 3
Glycogen Synthase Kinases
Molecular Sequence Data
Mutation
Phenotype
Protozoan Proteins*
Spores, Fungal / cytology
|
| IF |
38.637
|
| 引用数 |
176
|
|
WOS 分野
|
BIOCHEMISTRY & MOLECULAR BIOLOGY
CELL BIOLOGY
|
| リソース情報 |
| 細胞性粘菌 |
S00140 |
