RRC ID 28996
著者 Fisher PR, Noegel AA, Fechheimer M, Rivero F, Prassler J, Gerisch G.
タイトル Photosensory and thermosensory responses in Dictyostelium slugs are specifically impaired by absence of the F-actin cross-linking gelation factor (ABP-120).
ジャーナル Curr Biol
Abstract Chemotactic aggregation of starving amoebae of Dictyostelium discoideum leads to formation of a motile, multicellular organism - the slug - whose anterior tip controls its phototactic and thermotactic behaviour. To determine whether proteins that regulate the in vitro assembly of actin are involved in these responses, we tested phototaxis and thermotaxis in mutant slugs in which the gene encoding one of five actin-binding proteins had been disrupted. Of the proteins tested - severin, alpha-actinin, fimbrin, the 34 kD actin-bundling protein and the F-actin cross-linking gelation factor (ABP-120) - only ABP-120 proved essential for normal phototaxis and thermotaxis in the multicellular slugs. The related human protein ABP-280 is required for protein phosphorylation cascades initiated by lysophosphatidic acid and tumor necrosis factor alpha. The repeating segments constituting the rod domains of ABP-120 and ABP-280 may be crucial for the function of both proteins in specific signal transduction pathways by mediating interactions with regulatory proteins.
巻・号 7(11)
ページ 889-92
公開日 1997-11-1
DOI 10.1016/s0960-9822(06)00379-4
PII S0960-9822(06)00379-4
PMID 9480045
MeSH Actins / metabolism* Animals Carrier Proteins / genetics* Cell Movement / genetics* Dictyostelium / genetics* Fungal Proteins / genetics Gene Deletion* Hot Temperature Microfilament Proteins / genetics* Photoreceptor Cells, Invertebrate / physiology* Protozoan Proteins*
IF 9.601
引用数 32
WOS 分野 BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY
リソース情報
細胞性粘菌 S00412