| RRC ID |
29768
|
| 著者 |
White BJ, Hochhauser SJ, Cintron NM, Weiss B.
|
| タイトル |
Genetic mapping of xthA, the structural gene for exonuclease III in Escherichia coli K-12.
|
| ジャーナル |
J Bacteriol
|
| Abstract |
The genes xthA, pncA, and pabB were ordered relative to others by two- and three-factor transductional crosses with bacteriophage P1. The genes studied span 2 min (2%) of the genetic map of Escherichia coli K-12 in the clockwise sequence pheS-pfkB-xthA-pncA-gap-pabB-fadD. Eleven independently derived xth mutations were examined; all were known to affect exonuclease III and its associated endonuclease II activity, and all were mapped in the xthA region. pncA mutations were found to confer resistance to 6-aminonicotinamide, whereas some pheS mutations are known to specify resistance to p-fluorphenylalanine. xth mutations were readily transferred into other strains by selecting for these co-transducible drug resistance markers.
|
| 巻・号 |
126(3)
|
| ページ |
1082-8
|
| 公開日 |
1976-6-1
|
| DOI |
10.1128/jb.126.3.1082-1088.1976
|
| PMID |
780339
|
| PMC |
PMC233128
|
| MeSH |
6-Aminonicotinamide / pharmacology
Chromosome Mapping
Deoxyribonucleases / biosynthesis
Drug Resistance, Microbial
Endonucleases / metabolism
Escherichia coli / drug effects
Escherichia coli / enzymology*
Exonucleases / biosynthesis*
Genes*
Transduction, Genetic
p-Fluorophenylalanine / pharmacology
|
| IF |
3.006
|
| リソース情報 |
| 原核生物(大腸菌) |
ME8644 |
