論文 - 詳細
| RRC ID | 29988 |
|---|---|
| 著者 | Low B, Gates F, Goldstein T, Söll D. |
| タイトル | Isolation and partial characterization of temperature-sensitive Escherichia coli mutants with altered leucyl- and seryl-transfer ribonucleic acid synthetases. |
| ジャーナル | J Bacteriol |
| Abstract |
Two temperature-sensitive mutants of Escherichia coli have been found in which the conditional growth is a result of a thermosensitive leucyl-transfer ribonucleic acid (tRNA) synthetase and seryl-tRNA synthetase, respectively. The corresponding genetic loci, leuS and serS, cotransduce with lip and serC, respectively. As a result of the mutationally altered leucyl-tRNA synthetase, some leucine-, valine-, and isoleucine-forming enzymes were derepressed. Thus, leucyl-tRNA synthetase is involved in the repression of the enzymes needed for the synthesis of branched-chain amino acids. |
| 巻・号 | 108(2) |
| ページ | 742-50 |
| 公開日 | 1971-11-1 |
| DOI | 10.1128/jb.108.2.742-750.1971 |
| PMID | 4942762 |
| PMC | PMC247134 |
| MeSH | Acylation Amino Acids / metabolism Amino Acyl-tRNA Synthetases / metabolism* Carbon Isotopes Cell-Free System Chromosome Mapping Crosses, Genetic Culture Media Enzyme Repression Escherichia coli / enzymology* Escherichia coli / growth & development Escherichia coli / isolation & purification Escherichia coli / metabolism Genetics, Microbial* Immune Sera Isoleucine / biosynthesis Leucine / biosynthesis Mutagens Mutation* Nitrosoguanidines Serine Temperature* Transduction, Genetic Valine / biosynthesis |
| IF | 3.006 |
| リソース情報 | |
| 原核生物(大腸菌) | ME5398 ME8778 |