RRC ID 35307
著者 Williams AB, Hetrick KM, Foster PL.
タイトル Interplay of DNA repair, homologous recombination, and DNA polymerases in resistance to the DNA damaging agent 4-nitroquinoline-1-oxide in Escherichia coli.
ジャーナル DNA Repair (Amst)
Abstract Escherichia coli has three DNA damage-inducible DNA polymerases: DNA polymerase II (Pol II), DNA polymerase IV (Pol IV), and DNA polymerase V (Pol V). While the in vivo function of Pol V is well understood, the precise roles of Pol IV and Pol II in DNA replication and repair are not as clear. Study of these polymerases has largely focused on their participation in the recovery of failed replication forks, translesion DNA synthesis, and origin-independent DNA replication. However, their roles in other repair and recombination pathways in E. coli have not been extensively examined. This study investigated how E. coli's inducible DNA polymerases and various DNA repair and recombination pathways function together to convey resistance to 4-nitroquinoline-1-oxide (NQO), a DNA damaging agent that produces replication blocking DNA base adducts. The data suggest that full resistance to this compound depends upon an intricate interplay among the activities of the inducible DNA polymerases and recombination. The data also suggest new relationships between the different pathways that process recombination intermediates.
巻・号 9(10)
ページ 1090-7
公開日 2010-10-5
DOI 10.1016/j.dnarep.2010.07.008
PII S1568-7864(10)00238-7
PMID 20724226
PMC PMC2949549
MeSH 4-Nitroquinoline-1-oxide / metabolism* DNA Damage DNA Repair* DNA Replication DNA, Bacterial / genetics DNA, Bacterial / metabolism DNA-Directed DNA Polymerase / genetics DNA-Directed DNA Polymerase / metabolism* Escherichia coli / genetics Escherichia coli / metabolism* Escherichia coli Proteins / metabolism Mutagens / metabolism Recombination, Genetic Sequence Homology, Nucleic Acid*
IF 3.339
引用数 16
WOS 分野 TOXICOLOGY GENETICS & HEREDITY
リソース情報
原核生物(大腸菌) JW1172-KC