RRC ID |
35596
|
著者 |
Hase Y, Tarusawa T, Muto A, Himeno H.
|
タイトル |
Impairment of ribosome maturation or function confers salt resistance on Escherichia coli cells.
|
ジャーナル |
PLoS One
|
Abstract |
We found that loss of integrity of the ribosome by removal of a putative ribosome maturation factor or a ribosomal protein conferred salt tolerance on Escherichia coli cells. Some protein synthesis inhibitors including kasugamycin and chloramphenicol also had a similar effect, although kasugamycin affected neither 16S rRNA maturation nor subunit association into a 70S ribosome. Thus, salt tolerance is a common feature of cells in which maturation or function of the ribosome is impaired. In these cells, premature induction of an alternative sigma factor, σ(E), by salt stress was observed. These results suggest the existence of a yet-unknown stress response pathway mediated by the bacterial ribosome.
|
巻・号 |
8(5)
|
ページ |
e65747
|
公開日 |
2013-1-1
|
DOI |
10.1371/journal.pone.0065747
|
PII |
PONE-D-12-39672
|
PMID |
23741511
|
PMC |
PMC3669203
|
MeSH |
Aminoglycosides / pharmacology
Anti-Bacterial Agents / pharmacology
DNA / biosynthesis
DNA Replication / drug effects
Escherichia coli / genetics*
Escherichia coli / metabolism*
Escherichia coli Proteins / genetics
Gene Expression Regulation, Bacterial / drug effects
Mutation
RNA, Ribosomal, 16S / genetics
RNA, Ribosomal, 16S / metabolism
Ribosomes / metabolism*
Salt Tolerance / genetics*
Sigma Factor / metabolism
Stress, Physiological / genetics
|
IF |
2.74
|
引用数 |
7
|
WOS 分野
|
BIOCHEMISTRY & MOLECULAR BIOLOGY
|
リソース情報 |
原核生物(大腸菌) |
ME9062(BW25113) |