論文 - 詳細
RRC ID | 35722 |
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著者 | Takahashi Y, Sawada G, Kurashige J, Uchi R, Matsumura T, Ueo H, Takano Y, Akiyoshi S, Eguchi H, Sudo T, Sugimachi K, Doki Y, Mori M, Mimori K. |
タイトル | Paired related homoeobox 1, a new EMT inducer, is involved in metastasis and poor prognosis in colorectal cancer. |
ジャーナル | Br J Cancer |
Abstract |
BACKGROUND:Paired related homoeobox 1 (PRRX1) has been identified as a new epithelial-mesenchymal transition (EMT) inducer in breast cancer. However, the function of PRRX1 in colorectal cancer (CRC) has not been elucidated. METHODS:We utilised ectopic PRRX1-expressing cell lines to analyse the function of PRRX1 in CRC. The clinical significance of PRRX1 was also examined on three independent CRC case sets. RESULTS:PRRX1 induced EMT and the stem-like phenotype in CRC cells. In contrast to studies of breast cancer, abundant expression of PRRX1 was significantly associated with metastasis and poor prognosis in CRC. CONCLUSION:PRRX1 is an indicator of metastasis and poor prognosis in CRC cases. Further investigation is required to uncover the signalling network regulating PRRX1. |
巻・号 | 109(2) |
ページ | 307-11 |
公開日 | 2013-7-23 |
DOI | 10.1038/bjc.2013.339 |
PII | bjc2013339 |
PMID | 23807160 |
PMC | PMC3721401 |
MeSH | Carcinoma / diagnosis* Carcinoma / genetics Carcinoma / mortality Carcinoma / pathology* Cell Adhesion / genetics Cell Line, Tumor Cell Proliferation Colorectal Neoplasms / diagnosis* Colorectal Neoplasms / genetics Colorectal Neoplasms / mortality Colorectal Neoplasms / pathology* Epithelial-Mesenchymal Transition / genetics* Gene Expression Regulation, Neoplastic / physiology Homeodomain Proteins / genetics Homeodomain Proteins / physiology* Humans Meta-Analysis as Topic Neoplasm Metastasis Prognosis Survival Analysis Transfection Up-Regulation / genetics |
IF | 5.791 |
引用数 | 46 |
WOS 分野 | ONCOLOGY |
リソース情報 | |
遺伝子材料 | pCMV-VSV-G-RSV-Rev (RDB04393) pCAG-HIVgp (RDB04394) CSII-CMV-MCS (RDB04377). |