RRC ID 49547
著者 Rhind N, Chen Z, Yassour M, Thompson DA, Haas BJ, Habib N, Wapinski I, Roy S, Lin MF, Heiman DI, Young SK, Furuya K, Guo Y, Pidoux A, Chen HM, Robbertse B, Goldberg JM, Aoki K, Bayne EH, Berlin AM, Desjardins CA, Dobbs E, Dukaj L, Fan L, FitzGerald MG, French C, Gujja S, Hansen K, Keifenheim D, Levin JZ, Mosher RA, Müller CA, Pfiffner J, Priest M, Russ C, Smialowska A, Swoboda P, Sykes SM, Vaughn M, Vengrova S, Yoder R, Zeng Q, Allshire R, Baulcombe D, Birren BW, Brown W, Ekwall K, Kellis M, Leatherwood J, Levin H, Margalit H, Martienssen R, Nieduszynski CA, Spatafora JW, Friedman N, Dalgaard JZ, Baumann P, Niki H, Regev A, Nusbaum C.
タイトル Comparative functional genomics of the fission yeasts.
ジャーナル Science
Abstract The fission yeast clade--comprising Schizosaccharomyces pombe, S. octosporus, S. cryophilus, and S. japonicus--occupies the basal branch of Ascomycete fungi and is an important model of eukaryote biology. A comparative annotation of these genomes identified a near extinction of transposons and the associated innovation of transposon-free centromeres. Expression analysis established that meiotic genes are subject to antisense transcription during vegetative growth, which suggests a mechanism for their tight regulation. In addition, trans-acting regulators control new genes within the context of expanded functional modules for meiosis and stress response. Differences in gene content and regulation also explain why, unlike the budding yeast of Saccharomycotina, fission yeasts cannot use ethanol as a primary carbon source. These analyses elucidate the genome structure and gene regulation of fission yeast and provide tools for investigation across the Schizosaccharomyces clade.
巻・号 332(6032)
ページ 930-6
公開日 2011-5-20
DOI 10.1126/science.1203357
PII science.1203357
PMID 21511999
PMC PMC3131103
MeSH Centromere / genetics Centromere / physiology Centromere / ultrastructure DNA Transposable Elements Evolution, Molecular Gene Expression Profiling Gene Expression Regulation, Fungal Genes, Mating Type, Fungal Genome, Fungal* Genomics Glucose / metabolism Meiosis Molecular Sequence Annotation Molecular Sequence Data Phylogeny RNA, Antisense / genetics RNA, Fungal / genetics RNA, Small Interfering / genetics RNA, Untranslated / genetics Regulatory Elements, Transcriptional Schizosaccharomyces / genetics* Schizosaccharomyces / growth & development Schizosaccharomyces / metabolism Schizosaccharomyces pombe Proteins / genetics Schizosaccharomyces pombe Proteins / metabolism Sequence Analysis, DNA Species Specificity Transcription Factors / genetics Transcription Factors / metabolism Transcription, Genetic
IF 41.846
引用数 290
リソース情報
酵母 FY16936