論文 - 詳細
RRC ID | 50438 |
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著者 | Namiki S, Fujii T, Shimada T, Kanzaki R. |
タイトル | The morphology of antennal lobe projection neurons is controlled by a POU-domain transcription factor Bmacj6 in the silkmoth Bombyx mori. |
ジャーナル | Sci Rep |
Abstract |
How to wire a neural circuit is crucial for the functioning of the nervous system. Here, we describe the neuroanatomy of the olfactory neurons in the spli mutant strain of silkmoth (Bombyx mori) to investigate the function of a transcription factor involved in neuronal wiring in the central olfactory circuit. The genomic structure of the gene Bmacj6, which encodes a class IV POU domain transcription factor, is disrupted in the spli mutant. We report the neuroanatomical abnormality in the morphology of the antennal lobe projection neurons (PNs) that process the sex pheromone. In addition to the mis-targeting of dendrites and axons, we found axonal bifurcation within the PNs. These results indicate that the morphology of neurons in the pheromone processing pathway is modified by Bmacj6. |
巻・号 | 7(1) |
ページ | 14050 |
公開日 | 2017-10-25 |
DOI | 10.1038/s41598-017-14578-4 |
PII | 10.1038/s41598-017-14578-4 |
PMID | 29070905 |
PMC | PMC5656611 |
MeSH | Animals Arthropod Antennae / anatomy & histology* Arthropod Antennae / physiology* Axons / chemistry Axons / physiology Bombyx / physiology* Dendrites / chemistry Dendrites / physiology Gene Expression Regulation Image Processing, Computer-Assisted Insect Proteins / genetics Insect Proteins / metabolism* Neurons / chemistry Neurons / physiology* Olfactory Pathways POU Domain Factors / genetics POU Domain Factors / metabolism* Sex Attractants / metabolism Transcription Factors / genetics Transcription Factors / metabolism |
IF | 3.998 |
引用数 | 1 |
リソース情報 | |
カイコ | p50 n41 |