論文 - 詳細
| RRC ID | 56914 |
|---|---|
| 著者 | Satone H, Nonaka S, Lee JM, Shimasaki Y, Kusakabe T, Kawabata SI, Oshima Y. |
| タイトル | Tetrodotoxin- and tributyltin-binding abilities of recombinant pufferfish saxitoxin and tetrodotoxin binding proteins of Takifugu rubripes. |
| ジャーナル | Toxicon |
| Abstract |
We investigated the ability of recombinant pufferfish saxitoxin and tetrodotoxin binding protein types 1 and 2 of Takifugu rubripes (rTrub.PSTBP1 and rTrub.PSTBP2) to bind to tetrodotoxin (TTX) and tributyltin. Both rTrub.PSTBPs bound to tributyltin in an ultrafiltration binding assay but lost this ability on heat denaturation. In contrast, only rTrub.PSTBP2 bound to TTX even heat denaturation. This result suggests that the amino acid sequence of PSTBP2 may be contributed for its affinity for TTX. |
| 巻・号 | 125 |
| ページ | 50-52 |
| 公開日 | 2017-1-1 |
| DOI | 10.1016/j.toxicon.2016.11.245 |
| PII | S0041-0101(16)30576-1 |
| PMID | 27845057 |
| MeSH | Animals Fish Proteins / chemistry* Fish Proteins / isolation & purification Protein Binding Recombinant Proteins / chemistry* Takifugu* Tetrodotoxin / chemistry* Trialkyltin Compounds / chemistry* Ultrafiltration |
| IF | 2.276 |
| 引用数 | 3 |
| リソース情報 | |
| カイコ | d17 |