| RRC ID |
71823
|
| 著者 |
Tanaka M, Fujii T, Mon H, Lee JM, Kakino K, Fukumori H, Ebihara T, Nagasato T, Hino M, Tonooka Y, Moriyama T, Fujita R, Banno Y, Kusakabe T.
|
| タイトル |
Silkworm FoxL21 plays important roles as a regulator of ovarian development in both oogenesis and ovariole development.
|
| ジャーナル |
Insect Biochem Mol Biol
|
| Abstract |
The ovary is an important organ in reproduction. In insects, especially lepidopteran insects, the oocytes and reproductive organs develop rapidly during the pupal stage. Despite their drastic morphological changes, the molecular mechanisms of ovary development are not fully understood. In this study, it is found that forkhead box transcription factor L2, member 1 (FoxL21), which is known to be involved in ovarian differentiation and maintenance in vertebrates, is required for the development of the ovary in the silkworm, Bombyx mori. FoxL21 was expressed in the ovary and ovariole during the larval and pupal stage, respectively. In silkworms in which FoxL21 was knocked out by genome editing, multiple ovarian dysfunctions, such as, abnormal egg formation, thinning of the ovariole sheaths, and defective connection of the oviductus geminus with the ovariole were observed. Finally, ovarian transplantation experiments using the knockout silkworms revealed that FoxL21 functions in the ovariole, but not in the oviductus geminus.
|
| 巻・号 |
143
|
| ページ |
103737
|
| 公開日 |
2022-1-29
|
| DOI |
10.1016/j.ibmb.2022.103737
|
| PII |
S0965-1748(22)00019-4
|
| PMID |
35101566
|
| MeSH |
Animals
Bombyx* / genetics
Female
Oocytes
Oogenesis / genetics
Ovary
Pupa
|
| IF |
3.827
|
| リソース情報 |
| カイコ |
p55
p50
NB2 |
