論文 - 詳細
| RRC ID | 864 |
|---|---|
| 著者 | Takechi S, Yamaguchi T, Nomura H, Minematsu T, Nakayama T. |
| タイトル | Growth inhibition and mutagenesis induced in Escherichia coli by dihydropyrazines with DNA strand-cleaving activity. |
| ジャーナル | Mutat Res |
| Abstract |
Dihydropyrazine (DHP) causes DNA strand breaks in vitro. We evaluated the cytotoxic and genotoxic potential of DHP in Escherichia coli. DHP exposure dose-dependently caused inhibition of cell growth in the wild-type strain, death in recA and uvrB, and an increase in mutation frequency in uvrB. These findings indicate that DHP causes DNA strand breaks in vivo. |
| 巻・号 | 560(1) |
| ページ | 49-55 |
| 公開日 | 2004-5-9 |
| DOI | 10.1016/j.mrgentox.2004.02.007 |
| PII | S1383571804000476 |
| PMID | 15099824 |
| MeSH | DNA Damage DNA, Bacterial / drug effects* Escherichia coli / drug effects* Escherichia coli / genetics Escherichia coli / growth & development Mutagenesis Pyrazines / toxicity* |
| IF | 2.463 |
| 引用数 | 19 |
| WOS 分野 | TOXICOLOGY BIOTECHNOLOGY & APPLIED MICROBIOLOGY GENETICS & HEREDITY |
| リソース情報 | |
| 原核生物(大腸菌) | JE8478(GY6130) JE8479(QR140) ME8079(AB1157) ME8080(AB1885) ME8087(AB2463) ME8303(UM197) ME8299(UM119) ME8993(QC774) |