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Reference Info.
Pubmed ID 22330335  
RRC ID 21526 
Author Sakamoto K, Fujii T, Kawachi H, Miki Y, Omura K, Morita K, Kayamori K, Katsube K, Yamaguchi A. 
Title Reduction of NOTCH1 expression pertains to maturation abnormalities of keratinocytes in squamous neoplasms. 
Journal Lab. Invest. 
Published 2012-5 
Volume 92(5) 
Pages 688-702 
DOI 10.1038/labinvest.2012.9   
PII labinvest20129 
Carcinoma, Squamous Cell / genetics
Carcinoma, Squamous Cell / metabolism
Carcinoma, Squamous Cell / pathology*
Cell Differentiation
Cell Line, Tumor
Esophageal Neoplasms / genetics
Esophageal Neoplasms / metabolism
Esophageal Neoplasms / pathology*
Keratin-13 / genetics
Keratin-13 / metabolism
Keratin-15 / genetics
Keratin-15 / metabolism
Keratin-17 / genetics
Keratin-17 / metabolism
Keratinocytes / cytology
Keratinocytes / metabolism
Keratinocytes / pathology*
Keratins, Type I / genetics
Keratins, Type I / metabolism*
Mouth Neoplasms / genetics
Mouth Neoplasms / metabolism
Mouth Neoplasms / pathology*
Oligonucleotide Array Sequence Analysis
Precancerous Conditions / genetics
Precancerous Conditions / metabolism
Precancerous Conditions / pathology*
Receptor, Notch1 / genetics
Receptor, Notch1 / metabolism*
Uterine Cervical Neoplasms / genetics
Uterine Cervical Neoplasms / metabolism
Uterine Cervical Neoplasms / pathology*
Description Notch intracellular domainによるHES1転写活性化がRBPJ(論文中ではCBF1)に依存したパスウェイであることを示すためのRBPJの強制発現にpCMX-N/RBP-J が使用されました。 
Resource Info.
Species DNA material 
Resource name
pCMX-N/RBP-J (RDB03021

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