論文 - 詳細
| RRC ID | 12131 |
|---|---|
| 著者 | Wright MA, Mo W, Nicolson T, Ribera AB. |
| タイトル | In vivo evidence for transdifferentiation of peripheral neurons. |
| ジャーナル | Development |
| Abstract |
It is commonly thought that differentiated neurons do not give rise to new cells, severely limiting the potential for regeneration and repair of the mature nervous system. However, we have identified cells in zebrafish larvae that first differentiate into dorsal root ganglia sensory neurons but later acquire a sympathetic neuron phenotype. These transdifferentiating neurons are present in wild-type zebrafish. However, they are increased in number in larvae that have a mutant voltage-gated sodium channel gene, scn8aa. Sodium channel knock-down promotes migration of differentiated sensory neurons away from the ganglia. Once in a new environment, sensory neurons transdifferentiate regardless of sodium channel expression. These findings reveal an unsuspected plasticity in differentiated neurons that points to new strategies for treatment of nervous system disease. |
| 巻・号 | 137(18) |
| ページ | 3047-56 |
| 公開日 | 2010-9-1 |
| DOI | 10.1242/dev.052696 |
| PII | dev.052696 |
| PMID | 20685733 |
| PMC | PMC2926955 |
| MeSH | Animals Animals, Genetically Modified Cell Differentiation* Cell Movement Cell Transdifferentiation Ganglia, Spinal / cytology Ganglia, Spinal / embryology Ganglia, Spinal / metabolism Gene Expression Regulation, Developmental Mutation NAV1.6 Voltage-Gated Sodium Channel Neurons / cytology* Neurons / metabolism Sodium Channels / deficiency Sodium Channels / metabolism* Tyrosine 3-Monooxygenase / metabolism Zebrafish / growth & development* Zebrafish / metabolism Zebrafish Proteins / deficiency Zebrafish Proteins / metabolism* |
| IF | 5.611 |
| 引用数 | 15 |
| WOS 分野 | DEVELOPMENTAL BIOLOGY |
| リソース情報 | |
| ゼブラフィッシュ | rw0130a(Tg (Huc:Kaede)) |