論文 - 詳細
| RRC ID | 15397 |
|---|---|
| 著者 | Hashiyama K, Hayashi Y, Kobayashi S. |
| タイトル | Drosophila Sex lethal gene initiates female development in germline progenitors. |
| ジャーナル | Science |
| Abstract |
Sex determination in the Drosophila germ line is regulated by both the sex of the surrounding soma and cell-autonomous cues. How primordial germ cells (PGCs) initiate sexual development via cell-autonomous mechanisms is unclear. Here, we demonstrate that, in Drosophila, the Sex lethal (Sxl) gene acts autonomously in PGCs to induce female development. Sxl is transiently expressed in PGCs during their migration to the gonads; this expression, which was detected only in XX PGCs, is necessary for PGCs to assume a female fate. Ectopic expression of Sxl in XY PGCs was sufficient to induce them to enter oogenesis and produce functional eggs when transplanted into an XX host. Our data provide powerful evidence that Sxl initiates female germline fate during sexual development. |
| 巻・号 | 333(6044) |
| ページ | 885-8 |
| 公開日 | 2011-8-12 |
| DOI | 10.1126/science.1208146 |
| PII | science.1208146 |
| PMID | 21737698 |
| MeSH | Animals Animals, Genetically Modified Cell Movement Drosophila / embryology Drosophila / genetics* Drosophila / physiology Drosophila Proteins / genetics* Drosophila Proteins / physiology Embryo, Nonmammalian / physiology Embryonic Development Female Gene Expression Regulation, Developmental Genes, Insect Germ Cells / cytology Germ Cells / physiology* Germ Cells / transplantation Gonads / cytology* Gonads / embryology Male Oogenesis* RNA-Binding Proteins / genetics* RNA-Binding Proteins / physiology Sex Chromosomes Sex Determination Processes* |
| IF | 41.846 |
| 引用数 | 32 |
| WOS 分野 | DEVELOPMENTAL BIOLOGY |
| リソース情報 | |
| ショウジョウバエ | Stock(s) of Drosophila Geneitc Resource Center |