RRC ID |
15623
|
著者 |
Ongol MP, Iguchi T, Tanaka M, Sone T, Ikeda H, Asano K, Nishimura T.
|
タイトル |
Potential of selected strains of lactic acid bacteria to induce a Th1 immune profile.
|
ジャーナル |
Biosci Biotechnol Biochem
|
Abstract |
Lactic acid bacteria (LAB) might switch the Th2 biased immune response in allergic patients towards a balanced Th1/Th2 immune profile, leading to amelioration of allergy. To select strains of LAB that could be of potential application for foods in controlling allergy, 35 bacterial strains were screened in vitro using murine splenocytes and peritoneal exudate cells (PECs). Streptococcus thermophilus AHU1838 (FERM AP-21009), and Lactobacillus paracasei subsp. casei AHU1839 (FERM AP-21010) enhanced the secretion of Th1 cytokines such as interferon-gamma (IFN-gamma) and interleukin-12 (IL-12). The two strains of LAB also up-regulated the expression of CD40, and CD86 in dendritic cells (DCs), and activated cytotoxic T lymphocytes (CTL). These two strains could therefore be used in producing fermented food products that can enhance the Th1 immune profile which is important in ameliorating allergy.
|
巻・号 |
72(11)
|
ページ |
2847-57
|
公開日 |
2008-11-1
|
DOI |
10.1271/bbb.80307
|
PII |
JST.JSTAGE/bbb/80307
|
PMID |
18997432
|
MeSH |
Animals
Bacteria / classification
Bacteria / immunology*
Bacteria / metabolism*
Cattle
Cell Line, Tumor
Exudates and Transudates / cytology
Exudates and Transudates / immunology
Gene Expression Regulation
Interferon-gamma / metabolism
Interleukin-10 / metabolism
Interleukin-12 / metabolism
Lactic Acid / biosynthesis*
Mice
Monocytes / immunology
Peritoneum / metabolism
T-Lymphocytes, Cytotoxic / immunology
Th1 Cells / immunology*
|
IF |
1.516
|
引用数 |
18
|
WOS 分野
|
FOOD SCIENCE & TECHNOLOGY
CHEMISTRY, APPLIED
BIOTECHNOLOGY & APPLIED MICROBIOLOGY
BIOCHEMISTRY & MOLECULAR BIOLOGY
|
リソース情報 |
一般微生物 |
JCM 1001
JCM 1002
JCM 1025
JCM 1028
JCM 1034
JCM 1173
JCM 1192
JCM 5813
JCM 5818
JCM 7017
JCM 8787
JCM 8788
JCM 8790
JCM 11039 |