RRC ID |
18122
|
著者 |
Fujii T, Ikeda K, Saito M.
|
タイトル |
Inhibitory effect of rose hip (Rosa canina L.) on melanogenesis in mouse melanoma cells and on pigmentation in brown guinea pigs.
|
ジャーナル |
Biosci Biotechnol Biochem
|
Abstract |
The compounds present in rose hips exerting an inhibitory action against melanogenesis in B16 mouse melanoma cells were investigated by dividing an aqueous extract of rose hips (RE) into four fractions. The 50% ethanol eluate from a DIAION HP-20 column significantly reduced the production of melanin and was mainly composed of procyanidin glycosides. We also found that this 50% ethanol eluate reduced the intracellular tyrosinase activity and also had a direct inhibitory effect on tyrosinase obtained as a protein mixture from the melanoma cell lysate. We also investigated the effect of orally administering RE on skin pigmentation in brown guinea pigs, and found that the pigmentation was inhibited together with the tyrosinase activity in the skin. These data collectively suggest that proanthocyanidins from RE inhibited melanogenesis in mouse melanoma cells and guinea pig skin, and could be useful as a skin-whitening agent when taken orally.
|
巻・号 |
75(3)
|
ページ |
489-95
|
公開日 |
2011-1-1
|
DOI |
10.1271/bbb.100702
|
PII |
JST.JSTAGE/bbb/100702
|
PMID |
21389613
|
MeSH |
Administration, Oral
Animals
Arbutin / pharmacology
Cell Line, Tumor
Cell Survival / drug effects
Chromatography, High Pressure Liquid
Ethanol / chemistry
Female
Glycosides / pharmacology
Glycosides / therapeutic use
Guinea Pigs
Melanins / antagonists & inhibitors*
Melanins / biosynthesis
Melanoma, Experimental / drug therapy*
Melanoma, Experimental / physiopathology
Mice
Monophenol Monooxygenase / antagonists & inhibitors*
Monophenol Monooxygenase / metabolism
Plant Extracts / administration & dosage*
Plant Extracts / chemistry
Plant Extracts / therapeutic use
Proanthocyanidins / pharmacology
Proanthocyanidins / therapeutic use
Rosa / chemistry
Rosa / metabolism
Skin / drug effects
Skin / radiation effects
Skin Neoplasms / drug therapy*
Skin Neoplasms / physiopathology
Skin Pigmentation / drug effects
Skin Pigmentation / radiation effects
Ultraviolet Rays / adverse effects
|
IF |
1.516
|
引用数 |
19
|
WOS 分野
|
FOOD SCIENCE & TECHNOLOGY
BIOTECHNOLOGY & APPLIED MICROBIOLOGY
CHEMISTRY, APPLIED
BIOCHEMISTRY & MOLECULAR BIOLOGY
|
リソース情報 |
ヒト・動物細胞 |
B16 melanoma(RCB1283) |