| RRC ID |
18936
|
| Author |
Nakajima K, Komiyama Y, Hojo H, Ohba S, Yano F, Nishikawa N, Ihara S, Aburatani H, Takato T, Chung UI.
|
| Title |
Enhancement of bone formation ex vivo and in vivo by a helioxanthin-derivative.
|
| Journal |
Biochem Biophys Res Commun
|
| Abstract |
To effectively treat serious bone defects using bone-regenerative medicine, a small chemical compound that potently induces bone formation must be developed. We previously reported on the osteogenic effect of 4-(4-methoxyphenyl)pyrido[40,30:4,5]thieno[2,3-b]pyridine-2-carboxamide (TH), a helioxanthin-derivative, in vitro. Here, we report on TH's osteogenic effects ex vivo and in vivo. TH-induced new bone formation in both calvarial and metatarsal organ cultures. A novel monitoring system of osteoblastic differentiation using MC3T3-E1 cells revealed that TH was released from alpha-TCP bone cement and this release continued for more than one month. Lastly, the implantation of the alpha-TCP carrier containing TH into defects in mouse skull resulted in increased new bone areas within the defects after 4 weeks. A TH-containing scaffold may help establish a more efficient bone regeneration system.
|
| Volume |
395(4)
|
| Pages |
502-8
|
| Published |
2010-5-14
|
| DOI |
10.1016/j.bbrc.2010.04.041
|
| PII |
S0006-291X(10)00703-5
|
| PMID |
20382113
|
| MeSH |
3T3 Cells
Animals
Bone Regeneration*
Lignans / pharmacology*
Metatarsus
Mice
Organ Culture Techniques
Osteoblasts / drug effects*
Osteogenesis / drug effects*
Pyridines / pharmacology*
Skull
Thienopyridines
Thiophenes / pharmacology*
|
| IF |
2.985
|
| Times Cited |
9
|
|
WOS Category
|
BIOPHYSICS
BIOCHEMISTRY & MOLECULAR BIOLOGY
|
| Resource |
| Human and Animal Cells |
MC3T3-E1(RCB1126) |
