| RRC ID |
21266
|
| 著者 |
Akimoto T, Okuhira K, Aizawa K, Wada S, Honda H, Fukubayashi T, Ushida T.
|
| タイトル |
Skeletal muscle adaptation in response to mechanical stress in p130cas-/- mice.
|
| ジャーナル |
Am J Physiol Cell Physiol
|
| Abstract |
Mammalian skeletal muscles undergo adaptation in response to changes in the functional demands upon them, involving mechanical-stress-induced cellular signaling called "mechanotransduction." We hypothesized that p130Cas, which is reported to act as a mechanosensor that transduces mechanical extension into cellular signaling, plays an important role in maintaining and promoting skeletal muscle adaptation in response to mechanical stress via the p38 MAPK signaling pathway. We demonstrate that muscle-specific p130Cas-/- mice express the contractile proteins normally in skeletal muscle. Furthermore, muscle-specific p130Cas-/- mice show normal mechanical-stress-induced muscle adaptation, including exercise-induced IIb-to-IIa muscle fiber type transformation and hypertrophy. Finally, we provide evidence that exercise-induced p38 MAPK signaling is not impaired by the muscle-specific deletion of p130Cas. We conclude that p130Cas plays a limited role in mechanical-stress-induced skeletal muscle adaptation.
|
| 巻・号 |
304(6)
|
| ページ |
C541-7
|
| 公開日 |
2013-3-1
|
| DOI |
10.1152/ajpcell.00243.2012
|
| PII |
ajpcell.00243.2012
|
| PMID |
23325412
|
| MeSH |
Adaptation, Physiological*
Animals
Contractile Proteins / biosynthesis
Crk-Associated Substrate Protein / genetics
Crk-Associated Substrate Protein / physiology*
MAP Kinase Signaling System / physiology
Mechanotransduction, Cellular*
Mice
Mice, Knockout
Muscle Contraction / physiology
Muscle, Skeletal / metabolism
Muscle, Skeletal / physiology*
Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
Phosphorylation
Stress, Mechanical*
Stress, Physiological
Trans-Activators / metabolism
Transcription Factors
p38 Mitogen-Activated Protein Kinases / metabolism
|
| IF |
3.485
|
| 引用数 |
8
|
|
WOS 分野
|
PHYSIOLOGY
CELL BIOLOGY
|
| リソース情報 |
| 実験動物マウス |
RBRC02338 |
