論文 - 詳細
| RRC ID | 21799 |
|---|---|
| 著者 | Aoi Y, Arai K, Miyamoto M, Katsuta Y, Yamashita A, Sato M, Yamamoto M. |
| タイトル | Cuf2 boosts the transcription of APC/C activator Fzr1 to terminate the meiotic division cycle. |
| ジャーナル | EMBO Rep |
| Abstract |
The number of nuclear divisions in meiosis is strictly limited to two. Although the precise mechanism remains unknown, this seems to be achieved by adjusting the anaphase-promoting complex/cyclosome (APC/C) activity to degrade cyclin. Here, we describe a fission yeast cuf2 mutant that enters into a third nuclear division cycle, represented by ectopic spindle assembly and abnormal chromosome segregation. Cuf2 is a meiotic transcription factor, and its critical target is fzr1(+)/mfr1(+), which encodes a meiotic APC/C activator. fzr1Δ also enters a third nuclear division. Thus, Cuf2 ensures termination of the M-phase cycle by boosting Fzr1 expression to generate functional gametes. |
| 巻・号 | 14(6) |
| ページ | 553-60 |
| 公開日 | 2013-6-1 |
| DOI | 10.1038/embor.2013.52 |
| PII | embor201352 |
| PMID | 23628763 |
| PMC | PMC3674440 |
| MeSH | Cdh1 Proteins Cell Cycle Proteins / genetics* Cell Cycle Proteins / metabolism Cell Cycle Proteins / physiology* Cyclin B / metabolism Gene Expression Regulation, Fungal* Gene Knockout Techniques Meiosis* Schizosaccharomyces / cytology Schizosaccharomyces / physiology* Schizosaccharomyces pombe Proteins / genetics* Schizosaccharomyces pombe Proteins / metabolism Schizosaccharomyces pombe Proteins / physiology* Single-Cell Analysis Spores, Fungal / cytology Spores, Fungal / physiology Transcription, Genetic |
| IF | 7.497 |
| 引用数 | 9 |
| WOS 分野 | BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
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