Reference - Detail
| RRC ID | 21875 |
|---|---|
| Author | Rogulja D, Young MW. |
| Title | Control of sleep by cyclin A and its regulator. |
| Journal | Science |
| Abstract |
How and why the brain reversibly switches from a waking to a sleep state remain among the most intriguing questions in biology. We show that cyclin A (CycA) and regulator of cyclin A1, essential cell cycle factors, function in postmitotic neurons to promote sleep in Drosophila melanogaster. Reducing the abundance of CycA in neurons delayed the wake-sleep transition, caused multiple arousals from sleep, and reduced the homeostatic response to sleep deprivation. CycA is expressed in ~40 to 50 neurons in the adult brain, most of which are intermingled with circadian clock neurons, suggesting functional interactions among neurons controlling sleep and circadian behavior. |
| Volume | 335(6076) |
| Pages | 1617-21 |
| Published | 2012-3-30 |
| DOI | 10.1126/science.1212476 |
| PII | 335/6076/1617 |
| PMID | 22461610 |
| PMC | PMC3380085 |
| MeSH | Animals Brain / cytology Brain / metabolism Cell Cycle Proteins / genetics Cell Cycle Proteins / metabolism* Circadian Clocks Cyclin A / genetics Cyclin A / metabolism* Drosophila Proteins / genetics Drosophila Proteins / metabolism* Drosophila melanogaster / genetics Drosophila melanogaster / physiology* Female Genes, Insect Homeostasis Male Neurons / metabolism* Neuropeptides / genetics Neuropeptides / metabolism Period Circadian Proteins / genetics Period Circadian Proteins / metabolism Phenotype RNA Interference Sleep / physiology* Sleep Deprivation |
| IF | 41.846 |
| Times Cited | 48 |
| WOS Category | MULTIDISCIPLINARY SCIENCES |
| Resource | |
| Drosophila | 10800R-1 5940R-1 |