論文 - 詳細
| RRC ID | 2360 |
|---|---|
| 著者 | Miharada K, Hiroyama T, Sudo K, Nagasawa T, Nakamura Y. |
| タイトル | Efficient enucleation of erythroblasts differentiated in vitro from hematopoietic stem and progenitor cells. |
| ジャーナル | Nat Biotechnol |
| Abstract |
Erythroblast enucleation is thought to be largely dependent on signals mediated by other cells, such as macrophages. In an attempt to improve the in vitro production of red blood cells (RBCs) from immature hematopoietic progenitor cells, we have developed a method to produce enucleated RBCs efficiently in the absence of feeder cells. Our method may represent an efficient way to produce transfusable RBCs on a large scale from hematopoietic progenitors. |
| 巻・号 | 24(10) |
| ページ | 1255-6 |
| 公開日 | 2006-10-1 |
| DOI | 10.1038/nbt1245 |
| PII | nbt1245 |
| PMID | 16980975 |
| MeSH | Antigens, CD / metabolism Antigens, CD34 Cell Culture Techniques / methods Cell Differentiation Cell Nucleus Erythroblasts / cytology* Erythroblasts / physiology Glycophorins / metabolism Hematopoietic Stem Cells / cytology* Humans Receptors, Transferrin / metabolism |
| IF | 36.553 |
| 引用数 | 121 |
| WOS 分野 | BIOTECHNOLOGY & APPLIED MICROBIOLOGY |
| リソース情報 | |
| 研究用ヒト臍帯血幹細胞 | |