| RRC ID |
30444
|
| 著者 |
Inoue H, Tateno M, Fujimura-Kamada K, Takaesu G, Adachi-Yamada T, Ninomiya-Tsuji J, Irie K, Nishida Y, Matsumoto K.
|
| タイトル |
A Drosophila MAPKKK, D-MEKK1, mediates stress responses through activation of p38 MAPK.
|
| ジャーナル |
EMBO J
|
| Abstract |
In cultured mammalian cells, the p38 mitogen-activated protein kinase (MAPK) pathway is activated in response to a variety of environmental stresses. How ever, there is little evidence from in vivo studies to demonstrate a role for this pathway in the stress response. We identified a Drosophila MAPK kinase kinase (MAPKKK), D-MEKK1, which can activate p38 MAPK. D-MEKK1 is structurally similar to the mammalian MEKK4/MTK1 MAPKKK. D-MEKK1 kinase activity was activated in animals under conditions of high osmolarity. Drosophila mutants lacking D-MEKK1 were hypersensitive to environmental stresses, including elevated temperature and increased osmolarity. In these D-MEKK1 mutants, activation of Drosophila p38 MAPK in response to stress was poor compared with activation in wild-type animals. These results suggest that D-MEKK1 regulation of the p38 MAPK pathway is critical for the response to environmental stresses in Drosophila.
|
| 巻・号 |
20(19)
|
| ページ |
5421-30
|
| 公開日 |
2001-10-1
|
| DOI |
10.1093/emboj/20.19.5421
|
| PMID |
11574474
|
| PMC |
PMC125648
|
| MeSH |
Adaptation, Biological
Amino Acid Sequence
Animals
Drosophila / enzymology*
Environment
Enzyme Activation
MAP Kinase Signaling System*
Mitogen-Activated Protein Kinases / metabolism*
Molecular Sequence Data
Protein Serine-Threonine Kinases / metabolism*
Sequence Homology, Amino Acid
p38 Mitogen-Activated Protein Kinases
|
| IF |
9.889
|
| 引用数 |
64
|
|
WOS 分野
|
BIOCHEMISTRY & MOLECULAR BIOLOGY
CELL BIOLOGY
|
| リソース情報 |
| ショウジョウバエ |
DGRC#109805 |
