Reference - Detail
| RRC ID | 31350 |
|---|---|
| Author | Rottbauer W, Saurin AJ, Lickert H, Shen X, Burns CG, Wo ZG, Kemler R, Kingston R, Wu C, Fishman M. |
| Title | Reptin and pontin antagonistically regulate heart growth in zebrafish embryos. |
| Journal | Cell |
| Abstract |
Organ size is precisely regulated during development, but the control mechanisms remain obscure. We have isolated a mutation in zebrafish, liebeskummer (lik), which causes development of hyperplastic embryonic hearts. lik encodes Reptin, a component of a DNA-stimulated ATPase complex. The mutation activates ATPase activity of Reptin complexes and causes a cell-autonomous proliferation of cardiomyocytes to begin well after progenitors have fashioned the primitive heart tube. With regard to heart growth, beta-catenin and Pontin, a DNA-stimulated ATPase that is often part of complexes with Reptin, are in the same genetic pathways. Pontin reduction phenocopies the cardiac hyperplasia of the lik mutation. Thus, the Reptin/Pontin ratio serves to regulate heart growth during development, at least in part via the beta-catenin pathway. |
| Volume | 111(5) |
| Pages | 661-72 |
| Published | 2002-11-27 |
| DOI | 10.1016/s0092-8674(02)01112-1 |
| PII | S0092867402011121 |
| PMID | 12464178 |
| MeSH | ATP-Dependent Proteases Adenosine Triphosphatases / chemistry Adenosine Triphosphatases / physiology Amino Acid Sequence Animals Base Sequence Cardiomegaly / embryology Cardiomegaly / etiology Cardiomegaly / genetics Carrier Proteins Cell Division Conserved Sequence Cytoskeletal Proteins / physiology Embryo, Nonmammalian Enzyme Activation Gene Expression Regulation, Developmental Heart / embryology* Heat-Shock Proteins / physiology Molecular Sequence Data Myocardium / cytology Myocardium / ultrastructure Nuclear Proteins / genetics Nuclear Proteins / physiology* Point Mutation Sequence Homology, Amino Acid Serine Endopeptidases / physiology Trans-Activators / physiology Zebrafish Zebrafish Proteins / chemistry Zebrafish Proteins / genetics Zebrafish Proteins / physiology* beta Catenin |
| IF | 38.637 |
| Times Cited | 134 |
| WOS Category | BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
| Resource | |
| Medaka | Cab-Tg(zfmlc2 5.1k: DsRed2-nuc) (TG1026) |