論文 - 詳細
| RRC ID | 3308 |
|---|---|
| 著者 | Fuentes DE, Fuentes EL, Castro ME, Pérez JM, Araya MA, Chasteen TG, Pichuantes SE, Vásquez CC. |
| タイトル | Cysteine metabolism-related genes and bacterial resistance to potassium tellurite. |
| ジャーナル | J Bacteriol |
| Abstract |
Tellurite exerts a deleterious effect on a number of small molecules containing sulfur moieties that have a recognized role in cellular oxidative stress. Because cysteine is involved in the biosynthesis of glutathione and other sulfur-containing compounds, we investigated the expression of Geobacillus stearothermophilus V cysteine-related genes cobA, cysK, and iscS and Escherichia coli cysteine regulon genes under conditions that included the addition of K2TeO3 to the culture medium. Results showed that cell tolerance to tellurite correlates with the expression level of the cysteine metabolic genes and that these genes are up-regulated when tellurite is present in the growth medium. |
| 巻・号 | 189(24) |
| ページ | 8953-60 |
| 公開日 | 2007-12-1 |
| DOI | 10.1128/JB.01252-07 |
| PII | JB.01252-07 |
| PMID | 17951385 |
| PMC | PMC2168625 |
| MeSH | Alkyl and Aryl Transferases / biosynthesis Anti-Bacterial Agents / pharmacology* Bacillaceae / drug effects* Bacillaceae / genetics Bacillaceae / physiology Bacterial Proteins / biosynthesis Carbon-Sulfur Lyases / biosynthesis Cysteine / genetics* Cysteine / metabolism Cysteine Synthase / biosynthesis Escherichia coli / drug effects* Escherichia coli / genetics Escherichia coli / physiology Escherichia coli Proteins / biosynthesis Gene Expression Regulation, Bacterial / drug effects* Regulon Tellurium / pharmacology* |
| IF | 3.006 |
| 引用数 | 37 |
| WOS 分野 | MICROBIOLOGY |
| リソース情報 | |
| 原核生物(大腸菌) | JW2415 JW2720 JW2772 JW3582 JW3331 JW2732 JW2407 JW2414 JW2418 JW2416 JW3888 JW2514 JW2515 |