論文 - 詳細
RRC ID | 33526 |
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著者 | Shishido E, Takeichi M, Nose A. |
タイトル | Drosophila synapse formation: regulation by transmembrane protein with Leu-rich repeats, CAPRICIOUS. |
ジャーナル | Science |
Abstract |
Upon reaching the target region, neuronal growth cones transiently search through potential targets and form synaptic connections with only a subset of these. The capricious (caps) gene may regulate these processes in Drosophila. caps encodes a transmembrane protein with leucine-rich repeats (LRRs). During the formation of neuromuscular synapses, caps is expressed in a small number of synaptic partners, including muscle 12 and the motorneurons that innervate it. Loss-of-function and ectopic expression of caps alter the target specificity of muscle 12 motorneurons, indicating a role for caps in selective synapse formation. |
巻・号 | 280(5372) |
ページ | 2118-21 |
公開日 | 1998-6-26 |
DOI | 10.1126/science.280.5372.2118 |
PMID | 9641918 |
MeSH | Amino Acid Sequence Animals Cloning, Molecular Drosophila Proteins* Drosophila melanogaster Gene Expression Insect Proteins / chemistry Insect Proteins / genetics Insect Proteins / physiology* Membrane Proteins / chemistry Membrane Proteins / genetics Membrane Proteins / physiology* Molecular Sequence Data Motor Neurons / metabolism Muscles / innervation Muscles / metabolism Mutation Neuromuscular Junction / metabolism* Phenotype Signal Transduction Synapses / metabolism* |
IF | 41.846 |
引用数 | 91 |
WOS 分野 | NEUROSCIENCES |
リソース情報 | |
ショウジョウバエ |