| RRC ID |
33671
|
| 著者 |
Kishimoto N, Asakawa K, Madelaine R, Blader P, Kawakami K, Sawamoto K.
|
| タイトル |
Interhemispheric asymmetry of olfactory input-dependent neuronal specification in the adult brain.
|
| ジャーナル |
Nat Neurosci
|
| Abstract |
The vertebrate brain is anatomically and functionally asymmetric. The left and right cerebral hemispheres harbor neural stem cell niches at the ventricular-subventricular zone (V-SVZ) of the ventricular walls, where new neurons are continuously generated throughout life. However, any interhemispheric asymmetry of neural stem cell niches remains unclear. We performed gene-trap screens in adult zebrafish to identify genes that are differentially expressed in the two hemispheres and found that adult-born neurons expressing the neural zinc-finger protein Myt1 exist predominantly in the left V-SVZ. This lateralization could be reversed by left olfactory sensory deprivation-induced inactivation of Notch signaling. The olfactory behavioral preference for attractive amino acids was also impaired by sensory deprivation of the left olfactory system, but not of the right olfactory system. Our findings suggest that olfactory input generates interhemispheric differences in the fate of adult-born neurons in the zebrafish brain.
|
| 巻・号 |
16(7)
|
| ページ |
884-8
|
| 公開日 |
2013-7-1
|
| DOI |
10.1038/nn.3409
|
| PII |
nn.3409
|
| PMID |
23685722
|
| MeSH |
Age Factors
Amino Acids / metabolism
Amino Acids / pharmacology
Animals
Animals, Genetically Modified
Catheter Ablation
Cerebral Ventricles / metabolism
Dipeptides / pharmacology
Dose-Response Relationship, Drug
Enzyme Inhibitors / pharmacology
Epithelium / injuries
Epithelium / physiology
Functional Laterality / genetics
Functional Laterality / physiology*
Green Fluorescent Proteins / genetics
Green Fluorescent Proteins / metabolism
HSP70 Heat-Shock Proteins / metabolism
Injections, Intraventricular
Locomotion / drug effects
Locomotion / physiology
Nerve Tissue Proteins / metabolism
Neurons / physiology*
Odorants
Olfactory Bulb / cytology*
Olfactory Bulb / physiology
Olfactory Pathways / cytology
Olfactory Pathways / physiology*
Zebrafish
Zebrafish Proteins / genetics
|
| IF |
20.071
|
| 引用数 |
8
|
|
WOS 分野
|
NEUROSCIENCES
|
| リソース情報 |
| ゼブラフィッシュ |
SAGFF(LF)31B, UAS:GFP |
